Relationship between Serum Retinol Concentrations with Severity of Malaria

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Nwoye, E. O.
Olayemi, S. O.
Oreagba, I. A.
Temiye, E. O.
Adejare, A. A.
Ojobor, P. D.
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The Nigerian Journal of Pharmacy
Introduction: The effect of vitamin A supplementation in the reduction of childhood mortality has been known for some time however the more specific effect on malaria morbidity and mortality are less well documented. The objective of this study was to correlate serum retinol concentrations with severity of malaria using High Performance Liquid Chromatography Methods: Venous blood sample was taken for assay of baseline plasma retinol, packed cell volume and malaria parasite count patients between the ages of one and fifteen years with various severity of malaria ranging from moderate to severe malaria were selected to participate in the study. Result: Of 147 samples analysed, mean retinol levels did not correlate with parasite density but it correlated with the packed cell volume for all children with confirmed malaria parasite in their blood ( r=0.7469, Cl= 0.65 – 0.82, p=0.0001). Conclusion: Mean retinol level did not correlate significantly with parasite density but there is positive correlation between serum retinol and the packed cell volume