Solid state interaction of Pefloxacin with Zinc and Aluminium metal ions using Fourier Transform-Infrared spectroscopy.
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Nig. Qt J. Hosp. Med.
Background: Interaction between compounds in solvent medium is very common but reactions between compounds at the solid state are not common. It was reported that co-administration of quinolones with metal ion containing drug preparations, food supplements and fruit juices results in a reduction in bioavailability and the activity of quinolones. It was established, in vitro, that fluoroquinolones interact with metal ions and the antibacterial activity of the complex formed was lower than that of the pure fluoroquinolone . Objective: The objective of this study is to carry out an interaction between pefloxacin and some metal ions at the solid state without a solvent medium. Methods: Zn2+· and-Al3+ salts were used for the study. Pure pefloxacin was triturated with the metal ion salts at the solid state and the products obtained were analysed using fourier Transform-Infrared spectrophotometer. The spectra obtained were compared with that of pure pefloxacin. Results: A carbonyl absorption band at 1707 cm-1 was observed on pure pefloxacin spectrum. This band was not found on the pefloxacin-metal complexes' spectra. The disappearance of this band on the pefloxacin-metal complexes' spectra indicates an interaction at the carbonyl group with the metal ion without a solvent medium. Conclusion: Pefloxacin reacted with Zn2+ and Al3+ metal ions at the solid state.
Solid state interaction , Pefloxacin , Pefloxacin metal complex , Complexation , Research Subject Categories::PHARMACY::Pharmaceutical chemistry
Adepoju-Bello AA, Coker HAB, Abioye AO, Ezeagu II, Ayoola GA (2011). Solid state interaction of Pefloxacin with Zinc and Aluminium metal ions using Fourier Transform-Infrared spectroscopy. Nig. Qt J. Hosp. Med. 21 (3):175-178.