Direct Compression Studies on Low-Cost Cellulose derived from Maize Cob.
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Date
1994
Authors
Okhamafe, A.O.
Azubuike, C.P.
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Abstract
α-Celluloses were extracted from both the white and yellow varieties of de-grained corn cob, and then evaluated as direct compression diluents in paracetamol tablets using microcrystalline cellulose (Avicel®), a commercial diluent, as a standard. Based on the physicochemical and tablet parameters examined, e.g., tensile strength, disintegration time and dissolution, the extracted celluloses compared well with microcrystalline cellulose (MCC). They were highly compressible no binding agent was needed, and yielded paracetamol tablets that were self-lubricating (no lubricant was added), rapidly self-disintegrating (a disintegrant was not required) and facilitated high in vitro drug availability. The tablets were free from physical defects. Furthermore, the production costs of the extracted celluloses were substantially lower than the cost of MCC. The findings from this work further demonstrate the greater pharmaceutical potential of cellulose derived from agricultural wastes
Description
Staff publications
Keywords
De-grained corn cob , Paracetamol tablets , Microcrystalline cellulose , Microcrystalline cellulose (MCC) , Research Subject Categories::PHARMACY
Citation
Okhamafe, A.O. and Azubuike, C.P.C., (1994). Direct compression studies on low-cost cellulose derived from maize cob. J. Pharm. Sci. Pharm. Pract, 2, pp.26-29.