Preponderance of toxigenic Escherichia coli in stool pathogens correlates with toxin detection in accessible drinking-water sources.

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dc.contributor.authorIGBOKWE H.
dc.contributor.authorBhattacharyya S.
dc.contributor.authorGradus S.
dc.contributor.authorKhubbar M.
dc.contributor.authorGriswold D.
dc.contributor.authorNavidad J.
dc.contributor.authorIgwilo C.
dc.contributor.authorMasson-Meyers D.
dc.contributor.authorAzenabor A. A
dc.date.accessioned2022-01-16T19:01:20Z
dc.date.available2022-01-16T19:01:20Z
dc.date.issued2014
dc.description.abstractSince early detection of pathogens and their virulence factors contribute to intervention and control strategies, we assessed the enteropathogens in diarrhoea disease and investigated the link between toxigenic strains of Escherichia coli from stool and drinking-water sources; and determined the expression of toxin genes by antibiotic-resistant E. coli in Lagos, Nigeria. This was compared with isolates from diarrhoeal stool and water from Wisconsin, USA. The new Luminex xTAG GPP (Gastroplex) technique and conventional real-time PCR were used to profile enteric pathogens and E. coli toxin gene isolates, respectively. Results showed the pathogen profile of stool and indicated a relationship between E. coli toxin genes in water and stool from Lagos which was absent in Wisconsin isolates. The Gastroplex technique was efficient for multiple enteric pathogens and toxin gene detection. The co-existence of antibiotic resistance with enteroinvasive E. coli toxin genes suggests an additional prognostic burden on patients.en_US
dc.description.sponsorshipShaw Scientist Award to Professor A. A. Azenabor by the Greater Milwaukee Foundation, USA Milwaukee Health Department Laboratories, USA, University of Lagos, Nigeriaen_US
dc.identifier.citation1. IGBOKWE H., Bhattacharyya S., Gradus S., Khubbar M., Griswold D., Navidad J., Igwilo C., Masson-Meyers D. and Azenabor A. A. (2014). Preponderance of toxigenic Escherichia coli in stool pathogens correlates with toxin detection in accessible drinking-water sources. Journal of epidermiology and infection; 4(6): 1-24.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10428
dc.language.isoen_USen_US
dc.publisherJournal of epidermiology and infectionen_US
dc.subjectChronic diarrhoeaen_US
dc.subjectEscherichia coli toxinsen_US
dc.subjectMultiplex analysisen_US
dc.subjectStool pathogensen_US
dc.subjectWater sourcesen_US
dc.titlePreponderance of toxigenic Escherichia coli in stool pathogens correlates with toxin detection in accessible drinking-water sources.en_US
dc.typeArticleen_US
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