Biological Activity of Copper (Il), Cobalt (Il) and Nickel (Il) Complexes of Schiff Base Derived from O-phenylenediamine and 5-bromosalicylaldehyde

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Fasina, T.M.
Ogundele, O.
Ejiah, F.N.
Dueke-Eze, C.U.
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International journal of biological chemistry
Complexes of cobalt, nickel and copper ions with Schiff base derived from 5-bromosalicylaldehyde and o-phenylenediamine were synthesized and characterized usmg elemental analyses, molar conductance measurements, infrared and electronic spectroscopy. Elemental analysis data suggest the stoichiometry to be 1:1 [M:L] ratio formation in all complexes. The molar conductance measurements reveal the presence of non-electrolytic complexes. Comparison of the IR spectra of the Schiff base and the metal complexes indicate that the Schiff base is tetradentate and coordinates using the N202 chromophore. The electronic spectra data support octahedral geometry for cobalt (Il) complex, square planar geometry for nickel Ill) and copper (Il) complexes. The gyowth inhibitory potential of the Schiff base and the metal complexes against some clinically important bacteria, namely Staphylococcus a.ureus (AT CC 25923) Escherichia coli (AT CC 25922), Enterococcus feacalis (ATCC 29212) and Salmonella typhi show that the metal complexes are more potent than the parent Schiff base ligand against all tested bacterial strains.
Research Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistry::Coordination chemistry , Schiff base metal complexes , o-phenyienediamine , biological activity
Fasina, T. M., Ogundele, O., Ejiah, F. N., & Dueke-Eze, C. U. (2012). Biological Activity of copper (II), cobalt (II), and nickel (II) complexes of Schiff base derived from ophenylenediamine and 5-bromosalicylaldehyde. International Journal of Biological Chemistry, 6(1), 24-30.