SYNTHESIS AND ANTIBACTERIAL PROPERTY STUDIES OF THE N'-(4- SUBSTITUTED) ISONICOTINOHYDRAZIDES AND THEIR COPPER (II) COMPLEXES
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Date
2016
Authors
Fasina, T.M.
Dueke-Eze, C.U.
Familoni, O.B.
Idika, N.
Mphahlele, M.J.
Journal Title
Journal ISSN
Volume Title
Publisher
Ife Journal of Science
Abstract
A series of Schiff base ligands (L -L ) prepared by condensation of isonicotinic acid hydrazide with 1 4
substituted benzaldehydes and their corresponding copper(II) complexes (L A-L A) had been synthesized and 1 4
1
characterized based on IR, H NMR and electronic absorption spectroscopy as well as by molar conductivity and
elemental analyses. The in-vitro antimicrobial activity of the compounds against Staphylococcus aureus, Enterococcus
feacalis, Escherichia coli and Pseudomonas aeruginosa studied using agar ditch method indicated that the copper
complexes exhibited higher activity than the corresponding ligands. The antimicrobial activity of both the
ligands and complexes was dependent on the electronic effect of the halogen substituent, which decreased in the
order F > Cl > Br.
Description
Keywords
N-(4-substitutedbenzylidene) isonicotinohydrazide , Halogen Schiff Bases , Copper (II) Complexes , Antimicrobial Activity