Phytochemical screening, antimicrobial evaluation, and detection of caffeine and aspirin in herbal remedies used to treat typhoid fever

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dc.contributor.authorIgbokwe, N.H.
dc.contributor.authorAdeluola, A.O.
dc.contributor.authorIdowu, A.O.
dc.contributor.authorUgbo, S.
dc.date.accessioned2022-01-13T14:43:56Z
dc.date.available2022-01-13T14:43:56Z
dc.date.issued2018
dc.descriptionScholarly articlesen_US
dc.description.abstractThe use of herbal medicines among Nigerians and the tendency by patients to combine this class of medicines with allopathic drugs is on the increase. This study was carried out to evaluate the antimicrobial quality, phytochemical screening, and detection of orthodox drugs (caffeine and aspirin) present in locally prepared herbal remedies “ Agbo ” indicated for typhoid fever. Phytochemical screening of different herbal samples for typhoid was carried out. The antimicrobial activity of these samples was evaluated against enteric bacteria: Salmonella typhi, Escherichia coli, Proteus vulgaris, and Klebsiella pneumoniae . Investigation of the presence of aspirin and caffeine in most acidic samples was also carried out using High-Performance Liquid Chromatography (HPLC). The investigated herbal remedies for typhoid fever revealed an array of potential phytochemicals: Alkaloids, Saponins, Tannins, Cardiac glycosides, Reducing sugars, Flavonoids, Steroids, and Terpenoids. Only one (5%) of the 20 samples investigated possessed antimicrobial activity against the enteric organisms with minimal zone of inhibition. All the samples investigated possessed traces of caffeine while 70% contained caffeine and aspirin. Although the herbal preparations known as “ Agbo typhoid ” showed an array of phytochemicals, caution should be exercised in their consumption since they were found inactive against the causative organism for typhoid fever, Salmonella typhi. The introduction of orthodox drugs to herbal remedies is unacceptable since there could be unhealthy interactions. The presence of caffeine and aspirin in “ Agbo ” could be deleterious to healthen_US
dc.identifier.citationIgbokwe NH, AdeluolaAO,Idowu AO,Ugbo S.(2018)Phytochemical screening, antimicrobial evaluation, and detection of caffeine and aspirin in herbal remedies used to treat typhoid fever.J. Pharm. & Bioresources 15(2):77-86en_US
dc.identifier.issn0189-8442
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10319
dc.language.isoenen_US
dc.publisherJournal of Pharmacy and Bioresourcesen_US
dc.subjectPhytochemicalsen_US
dc.subjectOrthodox drugsen_US
dc.subjectAntimicrobial qualityen_US
dc.subjectPatientsen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titlePhytochemical screening, antimicrobial evaluation, and detection of caffeine and aspirin in herbal remedies used to treat typhoid feveren_US
dc.typeArticleen_US
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