Biological Activity of Copper(II), Cobalt(II) and Nickel(II) Complexes of Schiff Base Derived from o-phenylenediamine and 5- bromosalicylaldehyde

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Dueke-Eze, C.U.
Fasina, T.M.
Ogundele, O.
Ejiah, F.N.
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International Journal of Biological Chemistry
Complexes of cobalt, nickel and copper ions with Schiff base derived from 5-bromosalicylaldehyde and o-phenylenediamine were synthesized and characterized using elemental analyses, molar conductance measurements, infrared and electronic spectroscopy. Elemental analysis data suggest the stoichiometry to be 1:1 [M:L] ratio formation in all complexes. The molar conductance measurements reveal the presence of non-electrolytic complexes. Comparison of the IR spectra of the Schiff base and the metal complexes indicate that the Schiff base is tetradentate and coordinates using the N2O2 chromophore. The electronic spectra data support octahedral geometry for cobalt (II) complex, square planar geometry for nickel (II) and copper (II) complexes. The growth inhibitory potential of the Schiff base and the metal complexes against some clinically important bacteria, namely Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Enterococcus feacalis (ATCC 29212) and Salmonella typhi show that the metal complexes are more potent than the parent Schiff base ligand against all tested bacterial strains.
Research Subject Categories::NATURAL SCIENCES::Chemistry
T.M. Fasina, O. Ogundele, F.N. Ejiah and C.U. Dueke-Eze, 2012. Biological Activity of Copper (II), Cobalt (II) and Nickel (II) Complexes of Schiff Base Derived from O-phenylenediamine and 5-bromosalicylaldehyde. International Journal of Biological Chemistry, 6: 24-30.