Prevalence of Chlamydophilia Pneumonia antibodies in women with Pre-Eclampsia in Lagos, Nigeria

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dc.contributor.authorAwoleke, J.O
dc.contributor.authorAjayi, G.O
dc.contributor.authorAdegbola, O
dc.date.accessioned2020-03-03T10:10:30Z
dc.date.available2020-03-03T10:10:30Z
dc.date.issued2012
dc.descriptionStaff publicationsen_US
dc.description.abstractBACKGROUND: The precise aetiology of pre-eclampsia has remained unknown. It is still a major contributor to maternal and perinatal morbidity and mortality. OBJECTIVE: To determine the relationship between preeclampsia and immunoglobulin G (IgG) antibodies to Chlamydophila pneumoniae. METHODS: One hundred and eleven parturients in a tertiary hospital in Lagos, Nigeria comprising 49 women with preeclampsia and 62 women without pre-eclampsia were studied.Peripheral blood was obtained for Chlamydophila pneumoniae antibodies which were measured using a solidphase enzyme-linked immunosorbent assay and maternal diastolic blood pressure, perinatal morbidity and mortality were also assessed. RESULTS: The cases (N = 49) and controls (N = 62) were evenly matched with respect to age and parity. The women with pre-eclampsia delivered at significantly lower gestational ages than those with normotensive gestations. 66.7% of all the subjects were seropositive for Chlamydophila pneumoniae antibodies. 38 out of the 49 cases (77.6%) were positive for the Chlamydophila pneumoniae antibodies compared with 36 out of the 62 controls (58.1%) [p<0.05].Higher antibody titres were found in parous women with a previous history of preeclampsia compared with those without a previous history (p = 0.0308).However, there was no significant association between antibody titres and pregnancy outcome (p > 0.05). CONCLUSION: Results from this study suggest a link between Chlamydophila pneumoniae IgG antibodies and pre-eclampsia. Further prospective studies with larger sizes are needed to verify this association and identify therapeutic options that will effectively prevent the onset or progression of preeclampsia.en_US
dc.identifier.citationAwoleke, J.O. Ajayi, G.O. & Adegbola, O. (2012). Prevalence of Chlamydophilia Pneumonia antibodies in women with Pre-Eclampsia in Lagos, Nigeria. West African Journal of Medicine, 31(4):253-258.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7999
dc.language.isoenen_US
dc.publisherWest African Medical Journalen_US
dc.relation.ispartofseriesWest African Journal of Medicine;Vol.31(4)
dc.subjectPre-eclampsiaen_US
dc.subjectChlamydophila pneumoniaeen_US
dc.subjectSeroprevalenceen_US
dc.subjectIgG antibodiesen_US
dc.subjectResearch Subject Categories::MEDICINE::Surgery::Obstetrics and women's diseases::Obstetrics and gynaecologyen_US
dc.titlePrevalence of Chlamydophilia Pneumonia antibodies in women with Pre-Eclampsia in Lagos, Nigeriaen_US
dc.typeArticleen_US
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