Analysis of Fifteen Brands of Ciprofloxacin hydrochloride tablets obtained from Lagos metropolis, Nigeria.
| dc.contributor.author | Adepoju-Bello A.A. | |
| dc.contributor.author | Ayoola G.A. | |
| dc.contributor.author | Coker H.A.B. | |
| dc.date.accessioned | 2022-01-04T11:29:13Z | |
| dc.date.available | 2022-01-04T11:29:13Z | |
| dc.date.issued | 2010 | |
| dc.description | Scholarly articles | en_US |
| dc.description.abstract | The importance of ciprofloxacin especially in the third world countries can be estimated by the high success rate recorded in some high morbidity and mortality ailments. It is then necessary that the various brands of ciprofloxacin in the market must contain the adequate amount of active ingredient as specified in the official pharmacopoeias. A well formulated dosage form of ciprofloxacin ensures that adequate amount of the active constituent of the drug is delivered to the recipient to produce the desired pharmacological response. A substandard formulated dosage form of ciprofloxacin will not produce the desired pharmacological response. This research was carried out to evaluate the physical qualities and percentage purities of some brands of ciprofloxacin hydrochloride in the Nigerian market. The British Pharmacopoeia (B.P) and United States Pharmacopoeia (U.S.P) methods were adopted for the physicochemical tests -weight uniformity, disintegration, friability and dissolution tests. Ultraviolet/visible spectrophotometric calibration plot method was developed for the quantitative assay. The concentration of each brand was derived from the regression equation obtained from the calibration plot. The results obtained showed that 100% of the brands conformed to the physicochemical compendia standards. According to the U.S.P. specification (90-110%), 73.33% of the brands analysed passed the quantitative assay, 26.67% failed (6.67% were below the U .S.P. range and 20.00% were above the range). Conformity of drugs to compendia requirements is very crucial to ensure that the adequate amount of drug required to elicit their pharmacological effect gets to its site of action. Lack of regular electricity supply is affecting the proper storage of drugs resulting in fast decomposition of drugs before the expiry date. Therefore, a regular analysis of drugs is necessary to ensure the administration of quality drugs for effective treatment with the desired result. All the brands analysed passed the physicochemical assay according to the compendia requirement but only 73.33% of the brands passed the quantitative assay, 26.67% failed (6.67% were below the U.S.P. range and 20.00% were above the range). Researchers should continue to carry out physicochemical tests and quantitative assay regularly on drugs manufactured within the country and those imported into the country to ensure that all drugs circulating in the country at any point in time conform to the compendia requirements. | en_US |
| dc.description.sponsorship | Self | en_US |
| dc.identifier.citation | Adepoju-Bello AA, Ayoola GA, Coker HAB, 2010. Analysis of Fifteen Brands of Ciprofloxacin hydrochloride tablets obtained from Lagos metropolis, Nigeria. The Nigeria Journal of Pharmacy 43 (1): 40-46. | en_US |
| dc.identifier.issn | 0331-670X | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/9931 | |
| dc.language.iso | en | en_US |
| dc.publisher | The Nigeria Journal of Pharmacy | en_US |
| dc.subject | Research Subject Categories::PHARMACY | en_US |
| dc.subject | Analysis | en_US |
| dc.subject | Physiochemical tests | en_US |
| dc.subject | Spectrophotometry | en_US |
| dc.subject | Ciprofloxacin | en_US |
| dc.subject | Research Subject Categories::MEDICINE | en_US |
| dc.title | Analysis of Fifteen Brands of Ciprofloxacin hydrochloride tablets obtained from Lagos metropolis, Nigeria. | en_US |
| dc.type | Article | en_US |