Chemoprotective potential of ethanol extract of Ganodermalucidum on Liver and Kidney Parameters in Plasmodium beghei-induced mice
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Date
2015
Authors
Adetuyi, B.O
Dairo J.O
Oluwole, E.O.
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International Journal of Chemistry and Chemical Processes
Abstract
The comparative efficacy of ethanolic extract of Ganoderma lucidum in Plasmodium berghei infected mice in comparism with chloroquine, an antimalarial drug of proven efficacy and safety were studied, there is a significant increase (P<0.05) in the liver and kidney AST compared to positive control, except for the mice treated with 100 ml of ethanolic extract of Ganoderma lucidum. Whereas there is a significant reduction in the serum AST compared to positive control. The serum ALT shows no statistical significant in the chloroquine extract compared with 100 ml ethanolic extract, but there is a statistically significant increase in 500 ml of ethanolic extract compared with positive control. The liver γGT showed a significant increase when compared with positive control, whereas serum shows a significant reduction in specific activity, when compared with positive control. 100 ml. 250 ml, 500 ml ethanolic extract and chloroquine shows no significant difference when compared with 500 ml, chloroquine and 250 ml ethanolic extract respectively. There is a decrease in body weight of the mice not treated, but a slight increase in the body weight of the mice treated with 100 ml ethanolic extract. But there is no significant difference in the weight of the negative control mice, compared with the mice treated with 500 ml ethanolic extract. There is no significant change in the blood glucose level of the mice treated with 500 ml ethanolic extract compared with the mice treated with 100 ml ethanolic extract, moreover, there is a significant decrease in the body glucose level of the negative control mice compared with the positive control mice, but changes occur as there is an increase in the blood glucose of the mice when treated with the 100 ml and 250 ml ethanolic extracts. Serum ALP shows no statistical significant in all groups except for the negative control mice, which shows an increase when compared with 500 ml ethanolic extract and positive control. Liver shows a significant reduction when compared with positive control except for the mice treated with chloroquine in the liver
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Adetuyi, B.O, Oluwole E.O, Dairo J.O: Chemoprotective potential of ethanol extract of Ganodermalucidum on Liver and Kidney Parameters in Plasmodium beghei-induced mice. IIARD International Journal of Applied Chemistry 2015; 1(8): 29-36. www.iiardonline.org