Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.

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dc.contributor.authorOkubadejo, N.U.
dc.contributor.authorBritton, A.
dc.contributor.authorCrews, C.
dc.contributor.authorAkinyemi, R.
dc.contributor.authorHardy, J.
dc.contributor.authorSingleton, A.
dc.contributor.authorBras, J.
dc.date.accessioned2019-11-02T14:46:47Z
dc.date.available2019-11-02T14:46:47Z
dc.date.issued2008-10-17
dc.description.abstractSeveral genetic variations have been associated with Parkinson disease in different populations over the past few years. Although a considerable number of worldwide populations have been screened for these variants, results from Sub-Saharan populations are very scarce in the literature. In the present report we have screened a cohort of Parkinson disease patients (n = 57) and healthy controls (n = 51) from Nigeria for mutations in the genes PRKN, LRRK2 and ATXN3. No pathogenic mutations were found in any of the genes. Hence, common pathogenic mutations in these genes, observed in several different populations, are not a frequent cause of Parkinson disease in Nigeria.en_US
dc.identifier.citationOkubadejo N, Britton A, Crews C, Akinyemi R, Hardy J, Singleton A, Bras J. Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3. PLoS One. 2008;3(10):e3421.en_US
dc.identifier.otherdoi: 10.1371/journal.pone.0003421
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6679
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLOS)en_US
dc.subjectParkinson diseaseen_US
dc.subjectGeneticsen_US
dc.subjectInheritanceen_US
dc.subjectLRRK2en_US
dc.subjectPRKNen_US
dc.subjectNigeriaen_US
dc.subjectAfricaen_US
dc.titleAnalysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.en_US
dc.typeArticleen_US
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