CD4 count as a predictor of adrenocortical insufficiency in persons with human immunodeficiency virus infection: How useful?
| dc.contributor.author | Odeniyi, I. | |
| dc.contributor.author | Fasanmade, O. | |
| dc.contributor.author | Ajala, M.O. | |
| dc.contributor.author | Ohwovoriole, A. | |
| dc.date.accessioned | 2019-11-12T12:07:11Z | |
| dc.date.available | 2019-11-12T12:07:11Z | |
| dc.date.issued | 2013-11 | |
| dc.description | Staff publications | en_US |
| dc.description.abstract | OBJECTIVE: To determine the usefulness of CD4 count in predicting adrenocortical insufficiency (AI) in persons with HIV infection. DESIGN: Experimental study involving people with HIV infection and healthy people. PARTICIPANTS: The participants were recruited from the Lagos University Teaching Hospital. Forty-three newly diagnosed, treatment naive persons with HIV (23 males and 20 females) and 70 (35 males and 35 females) HIV negative subjects completed the study. INTERVENTION: One microgram Synacthen(®) was given intravenously to stimulate the adrenal glands. MAIN OUTCOME MEASURES: Blood was collected for cortisol at 0 and 30 min after the injection of adrenocorticotropic hormone (ACTH) and CD4 count. RESULTS: Mean basal cortisol was 154.9 ± 27.2 nmol/L and 239.9 ± 31.6 nmol/L (P < 0.001); the 30-min post ACTH test, cortisol level was 354.8 ± 19.9 nmol/L and 870.9 ± 163.5 nmol/L (P < 0.001); the increment was 100.0 ± 17.2 nmol/L and 588.8 ± 143.4 nmol/L (P < 0.001) in HIV and healthy subject group; respectively. Using the diagnostic criteria for diagnosis of AI in this study, fifteen (34.8%) persons with HIV had AI. There was no significant correlation between basal cortisol levels and CD4 count in patients with HIV infection (r = -0.2, P = 0.198). There was no significant correlation between stimulated cortisol level and CD4 count in patients with HIV infection (r = -0.09, P = 0.516). CONCLUSION: CD4 count does not predict the presence or absence of AI. ACTH stimulation of the adrenal gland remains the acceptable standard. | en_US |
| dc.identifier.citation | Odeniyi IA, Fasanmade OA, Ajala MO, Ohwovoriole AE. CD4 count as a predictor of adrenocortical insufficiency in persons with human immunodeficiency virus infection: How useful? Indian J Endocrinol Metab. 2013 Nov;17(6):1012-7. doi: 10.4103/2230-8210.122615 | en_US |
| dc.identifier.issn | 2230-9500, 2230-8210 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/6828 | |
| dc.language.iso | en | en_US |
| dc.publisher | Medknow publications | en_US |
| dc.subject | adrenocorticotropic hormone (ACTH) | en_US |
| dc.subject | CD4 count | en_US |
| dc.subject | Cortisol | en_US |
| dc.subject | Human immunodeficiency virus | en_US |
| dc.subject | Research Subject Categories::MEDICINE | en_US |
| dc.title | CD4 count as a predictor of adrenocortical insufficiency in persons with human immunodeficiency virus infection: How useful? | en_US |
| dc.type | Article | en_US |