Correlation Between Height and Impacted Third Molars and Genetics Role in Third Molar Impaction

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dc.contributor.authorAdeyemo, W.L.
dc.contributor.authorJames, O.
dc.contributor.authorOladega, A.A.
dc.contributor.authorAdamson, O.O.
dc.contributor.authorAdekunle, A.A.
dc.contributor.authorOlorunsola, K.D.
dc.contributor.authorTamara, B.
dc.contributor.authorButali, A.
dc.date.accessioned2020-02-12T18:08:28Z
dc.date.available2020-02-12T18:08:28Z
dc.date.issued2020-02-01
dc.descriptionStaff publicationen_US
dc.description.abstractAim: This study sought to evaluate the relationship between height of an individual and presence of impaction of maxillary and mandibular third molars, and to determine the role of genetics in third molar impaction. Material and Methods: This was a case-control study, with cases consisted of 200 subjects with third molar impactions; and 200 controls without third molar impactions. Height of subjects was measured and saliva samples were collected from all the subjects. DNA was extracted from saliva samples. To investigate the role of selected genes in the aetiology of third molar impactions, Taqman Genotyping using SNPs identified for jaw growth, height and tooth agenesis was employed. Five candidate genes were investigated using 11 markers (SNPs). Results: The mean height of cases was significantly lower than that of the control subjects (P=0.04). No difference was found in allele frequency between cases and controls for 10 of the 11 SNPs. However, for rs6504591 the P-value was near significance (P= 0.07) with Odd Ratio of 2.131. Subjects with lower third molar impactions were significantly shorter than those who have fully erupted third molars. Conclusions: Subjects with lower third molar impactions were significantly shorter than those who have fully erupted third molars. We observed that individuals with third molar impaction tend to have T allele at the locus suggesting that the T allele at the locus may increase the risk for having an impacted third molar. The rs6504591 G/T variation on human chromosome 17 (WNT9B gene) appears to increase risk by 2 folds for impaction albeit with inability to detect significance due to small sample size. Keywords: Third molars; impactions; height; genetics; WNT9B https://rdcu.be/b03rqen_US
dc.description.sponsorshipThis research was conducted with supports from University of Lagos Central Research Committee (CRC) Grant (CRC NO/2014/05) to WLA and K99/R00 Grant DE0223/Robert Wood Johnson Foundation Grant (72429) to AB.en_US
dc.identifier.citationAdeyemo WL, James O, Oladega AA, Adamson OO, Adekunle AA, Olorunsola KD, Busch T, Butali A. (2020). Correlation between height and impacted third molars and genetics role in third molar impaction. J Maxillofac Oral Surg. doi: https://doi.org/10.1007/s12663-020-01336-9. https://rdcu.be/b03rqen_US
dc.identifier.otherdoi: https://doi.org/10.1007/s12663-020-01336-9
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7660
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectThird molaren_US
dc.subjectHeighten_US
dc.subjectGeneticsen_US
dc.subjectImpactionsen_US
dc.subjectResearch Subject Categories::ODONTOLOGYen_US
dc.titleCorrelation Between Height and Impacted Third Molars and Genetics Role in Third Molar Impactionen_US
dc.typeArticleen_US
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