Adrenocortical Function In Nigerians With Human Immunodeficiency Virus (HIV) Infection

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dc.contributor.authorOdeniyi, I.A
dc.contributor.authorFasanmade, O.A
dc.contributor.authorAjala, M.O
dc.contributor.authorOhwovoriole, A.E
dc.date.accessioned2019-11-08T16:06:42Z
dc.date.available2019-11-08T16:06:42Z
dc.date.issued2013
dc.descriptionStaff publicationsen_US
dc.description.abstractOBJECTIVE: This study sets out to determine the prevalence of adrenocortical insufficiency in persons with HIV infection by determining the response to low-dose (1 µg) ACTH stimulation. DESIGN: An experimental study involving people with HIV infection and healthy people. SETTING: The study group and the controls were recruited from the Lagos University Teaching Hospital (LUTH). PARTICIPANTS: forty-three newly diagnosed and treatment naïve persons with HIV (23 males and 20 females) and 70 (35 males and 35 females) HIV negative subjects completed the study. INTERVENTION: One µg Synacthen was given intravenously to stimulate the adrenal glands. MAIN OUTCOME MEASURES: Blood was collected for basal cortisol levels and 30 minutes after the injection of ACTH. Cortisol was assayed using ELISA. RESULTS: The mean basal cortisol was 154.9 ± 27.2 nmol/L and 239.9 ± 31.6 nmol/L (p<0.001); while the 30-minute post ACTH test cortisol level was 354.8 ± 19.9 nmol/L and 870.9 ± 163.5 nmol/L (p<0.001) and the increment was 100.0 ± 17.2 nmol/L and 588.8 ± 143.4 nmol/L (p<0.001) in HIV and healthy subject group respectively. Using the diagnostic criteria derived for the diagnosis of adrenocortical insufficiency in this study (30 minute cortisol level <380.2 nmol/L and increment from basal to stimulated cortisol level <158.5 nmol/L); fifteen (34.8%) persons with HIV had adrenal insufficiency. CONCLUSION: Adrenocortical insufficiency is common in persons with HIV infection, occurring in about 34.8% of patients studied. Clinically evident adrenocortical insufficiency is uncommon in persons with HIV.en_US
dc.identifier.citationOdeniyi IA, Fasanmade OA, Ajala MO, Ohwovoriole AE. Adrenocortical Function In Nigerians With Human Immunodeficiency Virus (HIV) Infection. Ghana Med J. 2013; 47(4):171-7.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6801
dc.language.isoenen_US
dc.relation.ispartofseriesGhana Med J.;Vol.47(4)
dc.subjectAdrenocorticotropic hormoneen_US
dc.subjectCortisolen_US
dc.subjectHuman Immunodeficiency Virusen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleAdrenocortical Function In Nigerians With Human Immunodeficiency Virus (HIV) Infectionen_US
dc.typeArticleen_US
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