Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association
| dc.contributor.author | Bentley, A.R | |
| dc.contributor.author | Doumatey, A.P | |
| dc.contributor.author | Cheng, G | |
| dc.contributor.author | Huang, H | |
| dc.contributor.author | Zhou, J | |
| dc.contributor.author | Fasanmade, O | |
| dc.contributor.author | Johnson, T | |
| dc.date.accessioned | 2019-11-14T08:00:23Z | |
| dc.date.available | 2019-11-14T08:00:23Z | |
| dc.date.issued | 2012-09 | |
| dc.description | Staff publications | en_US |
| dc.description.abstract | Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear. We investigated the HDLc-eGFR association in nondiabetic Han Chinese (HC, n = 1100), West Africans (WA, n = 1497), and African Americans (AA, n = 1539). There were significant differences by ancestry: HDLc was positively associated with eGFR in HC (β = 0.13, P < 0.0001), but negatively associated among African ancestry populations (WA: -0.19, P < 0.0001; AA: -0.09, P = 0.02). These differences were also seen in nationally-representative NHANES data (among European Americans: 0.09, P = 0.005; among African Americans -0.14, P = 0.03). To further explore the findings in African ancestry populations, we investigated the role of an African ancestry-specific nephropathy risk variant, rs73885319, in the gene encoding HDL-associated APOL1. Among AA, an inverse HDLc-eGFR association was observed only with the risk genotype (-0.38 versus 0.001; P = 0.03). This interaction was not seen in WA. In summary, counter to expectation, an inverse HDLc-eGFR association was observed among those of African ancestry. Given the APOL1 × HDLc interaction among AA, genetic factors may contribute to this paradoxical association. Notably, these findings suggest that the unexplained mechanism by which APOL1 affects kidney-disease risk may involve HDLc. | en_US |
| dc.identifier.citation | Bentley AR, Doumatey AP, Chen G, Huang H, Zhou J, Shriner D, Jiang C, Zhang Z, Liu G, Fasanmade O, Johnson T, Oli J, Okafor G, Eghan BA Jr, Agyenim-Boateng K, Adeleye J, Balogun W, Adebamowo C, Amoah A, Acheampong J, Adeyemo A, Rotimi CN. Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. Int J Nephrol. 2012;2012:748984. doi: 10.1155/2012/748984 | en_US |
| dc.identifier.issn | 20902158, 2090214X | |
| dc.identifier.other | doi: 10.1155/2012/748984 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/6858 | |
| dc.language.iso | en | en_US |
| dc.publisher | Hindawi publishers | en_US |
| dc.subject | Cholesterol | en_US |
| dc.subject | Kidney disease | en_US |
| dc.subject | Genetic factors | en_US |
| dc.subject | Research Subject Categories::MEDICINE | en_US |
| dc.title | Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association | en_US |
| dc.type | Article | en_US |