Two-phase carcinogenesis in hamster buccal pouch
| dc.contributor.author | Odukoya, o | |
| dc.contributor.author | Shklar, G | |
| dc.date.accessioned | 2019-11-05T10:24:35Z | |
| dc.date.available | 2019-11-05T10:24:35Z | |
| dc.date.issued | 1982-11 | |
| dc.description | Staff publications | en_US |
| dc.description.abstract | A two-phase mechanism of chemical carcinogenesis in hamster buccal pouch has been demonstrated. Painting of buccal pouches three times weekly with a 0.1 percent solution of 7,12-dimethylbenz(a)anthracene (DMBA) in mineral oil for 10 weeks resulted in no visible tumors nor any microscopic evidence of dysplasia after the animals had been maintained for a 20 week period (Group 1 animals). Painting with 0.1 percent DMBA for 10 weeks, no treatment for a following 6 week period, and painting with 0.5 percent DMBA for a subsequent 4 weeks resulted in epidermoid carcinomas (Group 2 animals). Painting with 0.1 percent DMBA for 4 weeks in animals without prior treatment resulted in no tumors (Group 3 animals). It is postulated that the early treatment in Group 2 may serve for initiation and the later treatment for promotion. | en_US |
| dc.identifier.citation | Odukoya, O. and Shklar, G. Two phase carcinogenesis in the hamster buccal pouch. Oral Surg. Oral Med. Oral Pathol. 1982;54(5): 547-552. | en_US |
| dc.identifier.other | DOI: https://doi.org/10.1016/0030-4220(82)90193-1 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/6737 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Inc. | en_US |
| dc.subject | carcinogenesis | en_US |
| dc.subject | Mineral oil | en_US |
| dc.subject | Tumours | en_US |
| dc.subject | Treatment | en_US |
| dc.subject | Research Subject Categories::ODONTOLOGY::Oral pathology and forensic odontology | en_US |
| dc.title | Two-phase carcinogenesis in hamster buccal pouch | en_US |
| dc.type | Article | en_US |