Stability of reconstituted amoxicillin clavulanate potassium under simulated in-home storage conditions

dc.contributor.authorAkinleye, M.O.
dc.contributor.authorOyetunde, O.O.
dc.contributor.authorPEACE, N
dc.date.accessioned2019-09-16T12:33:39Z
dc.date.available2019-09-16T12:33:39Z
dc.date.issued2012-01-23
dc.description.abstractOral suspensions of antibiotics are mainly available as dry powders for reconstitution. Many reconstituted antibiotic suspension is to be kept refrigerated in order to get the optimal benefit from the drug. However, many patients do not keep to the specified storage conditions for different reasons like no refrigerator and irregular power supply that may result in variousdegrees of degradation of the product. Pharmacists are therefore challenged on how to counsel patients when there is no refrigeration or erratic power supply for refrigeration. This study investigated stability of amoxicillin-clavulanate potassium suspension in simulated in-home conditions of erratic power supply and no refrigeration. Amoxicilin clavulanate suspensions were reconstituted and stored in three different in-home storage conditions with temperature ranging between 5-29oC over a period of 10 days. Samples from the suspension were assayed using a validated HPLC method. Percentage concentrations of amoxicillin-clavulanate potassium were over 90% up to fifth day, degradation was extensive by seventh day with amoxicillin concentration falling below 80% in two conditions while clavulanate had values less than 70% in all the three conditions. Reconstituted amoxicillin clavunate potassium stored at room temperature (27-29oC) is stable for five days, use of reconstituted suspension that was not properly refrigerated after the fifth day should be discouraged.en_US
dc.identifier.citationStability of reconstituted amoxicillin clavulanate potassium under simulated in-home storage conditions N Peace, O Olubukola, A Moshood - Journal of Applied …, 2012 - japsonline.com Oral suspensions of antibiotics are mainly available as dry powders for reconstitution. Many reconstituted antibiotic suspension is to be kept refrigerated in order to get the optimal benefit from the drug. However, many patients do not keep to the specified storage …en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5565
dc.language.isoenen_US
dc.publisherJapsonlineen_US
dc.subjectstabilityen_US
dc.subjectamoxicillin-clavunate potassiumen_US
dc.subjecthome – storageen_US
dc.subjectsuspension.en_US
dc.titleStability of reconstituted amoxicillin clavulanate potassium under simulated in-home storage conditionsen_US
dc.typeArticleen_US
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