Phytochemical compounds from n-hexane extract of Uvaria chamae stem, Haematology and Genotoxicity evaluation of extract on selected organs in Mice

Simple item page
dc.contributor.authorOladipupo, A.R.
dc.contributor.authorAlaribe, S.C.
dc.contributor.authorBalogun, O.
dc.contributor.authorAkere, H.
dc.contributor.authorAyanda, F.
dc.contributor.authorToye, T.
dc.contributor.authorEmuejevoke, T.T.
dc.contributor.authorCoker Herbert, A.B.
dc.date.accessioned2022-01-19T12:58:58Z
dc.date.available2022-01-19T12:58:58Z
dc.date.issued2018
dc.descriptionScholarly articleen_US
dc.description.abstractPhytochemical constituents of plants extracts have been well investigated as leads for drug discovery and development. However, aside their immense medicinal properties, their safety is also of paramount importance, therefore evaluating the toxicity of plants extracts and their phytochemicals is an important aspect of quality measures to meet the requirements for consumption.This study was done to identify the volatile phytochemical compounds present in n-hexane extract of Uvaria chamae stems (UCSH) with the aid of gas chromatography-mass spectrometry (GC-MS) and to evaluate the effects of this non-polar extract on DNA using diphenylamine (DPA) and agarose gel electrophoresis assays, also to investigate the haematological parameters using an auto Haematology Analyzer.The GC-MS analysis of UCSH identified some compounds which include; squalene, lupeol, stigmasterol, β-sitosterol, and Benzyl benzoate with excellent medicinal properties. Genotoxicity assays results showed significant reductions in DNA fragmentation in liver and testis cells of mice as against the DNA biomarker and vehicle control group. Haematological results showed significant increase in white blood cells (WBC), red blood cell (RBC), platelets (PLT) and lymphocytes (LYMP) but significant reduction in mean corpuscular - volume (MCV), haemoglobin (MCH), and haemoglobin concentration (MCHC).The present study showed that the phytochemicals present in the n-Hexane extract of Uvaria chamae stems may play protective role in the genomic DNA of liver and testis tissues and also may induce hematological changes which may enhance the immune systemen_US
dc.identifier.citationOladipupo, A.R. Alaribe, S.C. Balogun, O. Akere, H. Ayanda, F. Toye, T. Emuejevoke, T.T. Coker Herbert, A.B. (2018). Phytochemical compounds from n-hexane extract of Uvaria chamae stem, Haematology and Genotoxicity evaluation of extract on selected organs in Miceen_US
dc.identifier.issnhttps://doi.org/10.2478/ast-2018-0012
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10551
dc.language.isoenen_US
dc.publisherAnnals of Science and Technology (AST)en_US
dc.subjectUvaria chamaeen_US
dc.subjectLiveren_US
dc.subjectTestisen_US
dc.subjectGenotoxicityen_US
dc.subjectHaematologyen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titlePhytochemical compounds from n-hexane extract of Uvaria chamae stem, Haematology and Genotoxicity evaluation of extract on selected organs in Miceen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
AST FULL PAPER, Genotoxicity , Uvaria chamae.pdf
Size:
917.8 KB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Pharmaceutical Chemistry- Scholarly Publications