Frequency and predictors of autonomic dysfunction in Parkinson's disease: a study of African patients in Lagos, Nigeria

Simple item page
dc.contributor.authorOkubadejo, N.U.
dc.contributor.authorDanesi, M.A.
dc.date.accessioned2019-11-04T07:56:13Z
dc.date.available2019-11-04T07:56:13Z
dc.date.issued2004-03
dc.descriptionStaff publicationsen_US
dc.description.abstractThe degenerative changes in PD also affect the autonomic nervous system. The frequency and predictors of such involvement in Africans with PD has not been reported. OBJECTIVE: i) To determine the frequency and type of autonomic dysfunction in Nigerians with idiopathic Parkinson's disease (PD). ii) To determine the predictors of autonomic dysfunction in PD. METHODS: Cardiovascular autonomic function assessed in 33 study subjects with PD and 33 age-matched controls, utilising heart rate variability to deep breathing, standing and the Valsalva manoeuvre, and the blood pressure (BP) response to standing. The results were compared based on treatment category, grade of severity on the Columbia scale of Hoehn and Yahr, duration of PD, age at onset of PD, present age and occurrence of autonomic symptoms. RESULTS: Parasympathetic function was abnormal in 51.5% of PD subjects, significantly higher than controls (P<0.001). Of these, 76.5% had early parasympathetic involvement and 23.5% definite parasympathetic involvement. Age above 65 years (at time of study or onset of PD) was the only clinical variable associated with parasympathetic autonomic dysfunction (p<0.05). Symptoms dysfunction occurred in 60.6% of PD patients and only 6.1% of controls (p<0. 001). There was however no demonstrable relationship between the occurrence of symptoms and objective evidence of autonomic dysfunction: 41.2% of PD patients with parasympathetic dysfunction had no symptoms. CONCLUSION: Autonomic dysfunction was found to be common in Africans with PD, particularly those above 65 years and tends to affect the parasympathetic system. However, the abnormality may be detectable even before symptoms appear. As such, we recommend that cardiovascular tests of autonomic function be a routine aspect of the evaluation of PD patients, especially with advancing age.en_US
dc.identifier.citationOkubadejo NU, Danesi MA. Frequency and predictors of autonomic dysfunction in Parkinson's disease: a study of African patients in Lagos, Nigeria. Niger Postgrad Med J. 2004 Mar;11(1):45-9.en_US
dc.identifier.otherPubMed PMID: 15254572.
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6712
dc.language.isoenen_US
dc.publisherNational Postgraduate Medical College of Nigeriaen_US
dc.subjectParkinson diseaseen_US
dc.subjectAutonomic dysfunctionen_US
dc.subjectNigeriaen_US
dc.subjectPredictorsen_US
dc.subjectHoehn and Yahr scaleen_US
dc.subjectAfricaen_US
dc.titleFrequency and predictors of autonomic dysfunction in Parkinson's disease: a study of African patients in Lagos, Nigeriaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Okubadejo NU et al. Frequency and predictors of autonomic dysfunction in Parkinson disease.pdf
Size:
2.31 MB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Medicine- Scholarly Publications