Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index

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dc.contributor.authorRotimi, C.N
dc.contributor.authorJohnson, T
dc.contributor.authorChen, G
dc.contributor.authorAdeyemo, A
dc.contributor.authorFasanmade, O
dc.contributor.authorShriner, D
dc.contributor.authorAcheampong, J
dc.contributor.authorOli, J
dc.contributor.authorDoumatey, A.P
dc.contributor.authorOkafor, G
dc.contributor.authorBentley, A.R
dc.date.accessioned2019-11-27T14:32:44Z
dc.date.available2019-11-27T14:32:44Z
dc.date.issued2017-04
dc.descriptionStaff publicationsen_US
dc.description.abstractOBJECTIVE: The prevalence of obesity varies between ethnic groups. No genome-wide association study (GWAS) for body mass index (BMI) has been conducted in continental Africans. METHODS: We performed a GWAS for BMI in 1,570 West Africans (WA). Replication was conducted in independent samples of WA (n = 1,411) and African Americans (AA) (n = 9,020). RESULTS: We identified a novel genome-wide significant African-specific locus for BMI (SEMA4D, rs80068415; minor allele frequency = 0.008, P = 2.10 × 10-8 ). This finding was replicated in independent samples of WA (P = 0.013) and AA (P = 0.017). Individuals with obesity had higher serum SEMA4D levels compared to those without obesity (P < 0.0001), and elevated levels of serum SEMA4D were associated with increased obesity risk (OR = 4.2, P < 1 × 10-4 ). The prevalence of obesity was higher in individuals with the CT versus TT genotypes (55.6% vs. 22.9%). CONCLUSIONS: A novel variant in SEMA4D was significantly associated with BMI. Carriers of the C allele were 4.6 BMI units heavier than carriers of the T allele (P = 0.0007). This variant is monomorphic in Europeans and Asians, highlighting the importance of studying diverse populations. While there is evidence for the involvement of SEMA4D in inflammatory processes, this study is the first to implicate SEMA4D in obesity pathophysiology.en_US
dc.description.sponsorshipSupport for participant recruitment and initial genetic studies of the AADM study was provided by NIH grant No. 3T37TW00041-03S2 from the National Institute of Minority Health and Health Disparities (NIMHD). The project was also supported in part by the NIDDK grant DK-54001.en_US
dc.identifier.citationChen G, Doumatey AP, Zhou J, Lei L, Bentley AR, Tekola-Ayele F, Adebamowo SN, Baker JL, Fasanmade O, Okafor G, Eghan B Jr, Agyenim-Boateng K, Amoah A, Adebamowo C, Acheampong J, Johnson T, Oli J, Shriner D, Adeyemo AA, Rotimi CN. Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index. Obesity (Silver Spring). 2017 Apr;25(4):794-800. doi: 10.1002/oby.21804.en_US
dc.identifier.issn19307381
dc.identifier.otherdoi: 10.1002/oby.21804
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7007
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectObesityen_US
dc.subjectGeneticsen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleGenome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass indexen_US
dc.typeArticleen_US
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