Toxicity of Mucuna pruriens seed extract on the kidney of adult Sprague-Dawley rats

dc.contributor.authorGbotolorun, S.C.
dc.contributor.authorIsah, P.K.
dc.contributor.authorAdebajo, O.A.
dc.date.accessioned2022-01-05T02:12:12Z
dc.date.available2022-01-05T02:12:12Z
dc.date.issued2018
dc.descriptionScholarly articlesen_US
dc.description.abstractBackground: The commonly acceptable knowledge that herbal medications have little or no toxicity and are absolutely safe makes people consume them indiscriminately. All parts of Mucuna pruriens have been reported to possess valuable medicinal properties, but its potential toxicity on vital organs remains unexplored. Objective: To determine the deleterious effect of Mucuna pruriens on the Kidney of Adult Sprague-Dawley Rats. Methodology: Twenty Sprague-Dawley rats were used and divided into four groups of five rats per group. Group I served as control and received distilled water and groups II-IV received 50, 100 and 200 mg/kg of the extract respectively for 2 weeks. The animals were sacrificed, blood was collected for kidney function test and the kidneys were excised via ventral laparatomy. The right kidney was fixed for histological studies while the left kidney was analysed for biochemical markers of oxidative stress Results: Lipid peroxidation increased significantly while superoxide dismutase and glutathione recorded a significant decrease in activities when the treated groups were compared to control. Creatinine decreased significantly and urea increased significantly when treated groups were compared to control. Histological sections showed degenerative changes and tubular necrosis in the kidney at higher doses. Conclusion: Mucuna pruriens causes degenerative changes in glomerular epithelia and reduced urea clearance possibly by an oxidative stress mechanism.en_US
dc.identifier.citationGbotolorun, S. C., Isah, P. K., & Adebajo, O. A. (2018). Toxicity of Mucuna pruriens seed extract on the kidney of adult Sprague-Dawley rats. African Journal of Pharmacology and Therapeutics, 7(1).en_US
dc.identifier.issn2303‐9841
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9949
dc.language.isoenen_US
dc.publisherThe Kenya Society for Basic and Applied Pharmacology (KeSoBAP)en_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.subjectKidneyen_US
dc.subjectUreaen_US
dc.subjectMucuna pruriensen_US
dc.subjectSuperoxide dismutaseen_US
dc.titleToxicity of Mucuna pruriens seed extract on the kidney of adult Sprague-Dawley ratsen_US
dc.typeArticleen_US
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