Microbial Metabolites and Enzymes Inhibition in Drug Discovery and Development: A Case Study of the Statins, a Class of HMG-CoA Reductase Inhibitors. Trop J Nat Prod Res

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dc.contributor.authorOladipupo, A.R.
dc.contributor.authorCoker, H.A.
dc.contributor.authorAlaribe, S.C.
dc.contributor.authorOgacheko, D.
dc.date.accessioned2022-09-13T11:16:52Z
dc.date.available2022-09-13T11:16:52Z
dc.date.issued2019
dc.descriptionScholarly articleen_US
dc.description.abstractThe discovery and development of the statins provides an insight into the many facets of the drug discovery process and also shows the time and resources that must be devoted to developing a clinically useful drug from an initial concept. It began from the conceptual search for metabolites that could inhibit an important enzyme in cholesterol biosynthesis, HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase, to the isolation of the first active metabolite, citrinin, from a fungus, leading to further search and development. This discovery is a milestone in medicine and a historical portrait, which illustrates the importance of multidisciplinary approach in drug development. The statins are the results of combined efforts of inter alia, pharmaceutical chemists, microbiologists, physiologists, and pharmacologists. This paper gives an account of the discovery of the statins, highlighting the clinical importance of cholesterol, the discovery of HMG-CoA reductase, and subsequent search for its inhibitors. It showcases the clinical importance and limitations of the statins and seeks to serve as a guide and inspiration for future discovery and development of novel, potent and safer cholesterol-lowering agents.en_US
dc.description.sponsorshipnoneen_US
dc.identifier.citation@article{Oladipupo2019MicrobialMA, doi.org/10.26538/tjnpr/v3i4.1en_US
dc.identifier.issnDOI:10.26538/tjnpr/v3i4.1
dc.identifier.issnISSN 2616-0684(Print)ISSN 2616-0692(Electronic)
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/11472
dc.language.isoenen_US
dc.publisherTropical Journal of Natural Product Researchen_US
dc.relation.ispartofseries;ISSN 2616-0684(Print)ISSN 2616-0692(Electronic)
dc.subjectDrug discoveryen_US
dc.subjectMicrobial metabolitesen_US
dc.subjectHMG-CoA reductase inhibitorsen_US
dc.subjectCholesterol-lowering agentsen_US
dc.subjectAkira Endoen_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleMicrobial Metabolites and Enzymes Inhibition in Drug Discovery and Development: A Case Study of the Statins, a Class of HMG-CoA Reductase Inhibitors. Trop J Nat Prod Resen_US
dc.typeArticleen_US
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