Role of the Peripheral Arterial Chemoreceptors in the Integrated Cardiovascular Response to Systematic Hypoxia

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dc.contributor.authorEgbengu, E.P.
dc.date.accessioned2018-09-12T11:31:24Z
dc.date.available2018-09-12T11:31:24Z
dc.date.issued1987
dc.descriptionFull Text Attacheden_US
dc.description.abstractExperiments were performed on healthy male and female mongrel dogs, anaesthetized with a sodium pentobarbitone. The animals were either allowed to breathe spontaneously or were artificially ventilated using a mechanical respirator. Systematic hypoxia was induced by allowing animals to breathe a hypoxia gas mixture containing 7% 02 in 93% nitrogen. Vascularly isolated carotid chemoreceptor areas were perfused at constant perfusion pressure through an extracorporeal circuit assembly with hypoxic blood or arterial blood obtained from an artificial membrane lung. The role of carotid chemoreceptor was assessed by perfusing the carotid bifurcation areas with arterial or normoxic blood, while the animal still breathe the hypoxic gas mixture. The role of aortic chemoreceptor was assessed by comparing cardiovascular responses to systemic hypoxia before and after bilateral mid-cervical vagotomy, since afferents from aortic and carotid chemoreceptor during systemic hypoxia was assessed by perfusing the carotid chemoreceptor with arterial blood in animals that were vagotomised. Cardiovascular variables measured included blood pressure (BP) hear rate (HR), left ventricular pressure (LVP), MAXIMUM RATE OF RISE of left ventricular pressure (LVdp/dt max) and femoral artery perfusion pressure (FAPP). The control values of these variables were determined and compared with the values during systemic hypoxia; systemic hypoxia with carotid withdrawal; systemic hypoxia with aortic withdrawal by vagotomy; and with systemic hypoxia with both carotid and aortic withdrawal.en_US
dc.description.sponsorshipUniversity of Lagosen_US
dc.identifier.citationEgbengu, E.P. ( 1987). Role of the Peripheral Arterial Chemoreceptors in the Integrated Cardiovascular Response to Systematic Hypoxia. Thesis Submitted in Fulfillment of the Requirements for the Degree Doctor of Philosophy (ph.D) in Physiology of the University of Lagos.en_US
dc.identifier.urihttp://ir.unilag.edu.ng:8080/xmlui/handle/123456789/3032
dc.language.isoenen_US
dc.publisherUniversity of Lagosen_US
dc.subjectPeripheral Arterialen_US
dc.subjectChemoreceptorsen_US
dc.subjectSystemic Hypoxiaen_US
dc.subjectCardiovascularen_US
dc.titleRole of the Peripheral Arterial Chemoreceptors in the Integrated Cardiovascular Response to Systematic Hypoxiaen_US
dc.typeThesisen_US
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