Synthesis and Antibacterial Activity of N,N- Diethylamide Bearing Benzenesulfonamide Derivatives

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dc.contributor.authorAjani, O.O.
dc.contributor.authorFamiloni, O.B.
dc.contributor.authorEcheme, J.O.
dc.contributor.authorWu, Feipeng
dc.contributor.authorSujiang, Z.
dc.date.accessioned2019-09-05T08:46:40Z
dc.date.available2019-09-05T08:46:40Z
dc.date.issued2013-01-25
dc.descriptionStaff publicationsen_US
dc.description.abstractSulfonamides are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of new N,N-diethyl amide bearing sulfonamides (2a-k) were synthesized via amidation of easily prepared benzenesulfonamide precursors (1a-k). The chemical structures of all synthesized compounds were substantiated using spectroscopic means such as IR, Mass spectra and 1H-NMR as well as analytical data. The antimicrobial activity of these compounds along with streptomycin, was investigated on Escherichia coli and Staphylococcus aureus. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was N,Ndiethyl-1-(phenylsulfonyl) piperidine-2-carboxamide (2b).en_US
dc.identifier.citationAjani, O. O.[Et...al] (2013). Synthesis and Antibacterial Activity of N, N-Diethylamide Bearing Benzenesulfonamide Derivatives. American Chemical Science Journal, Vol.3(1), 34-49.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5132
dc.language.isoenen_US
dc.publishereprints.covenantuniversity.edu.ngen_US
dc.relation.ispartofseriesAmerican Chemical Science Journal;Vol.3(1)
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Organic synthesisen_US
dc.subject2-(Phenylsulfonamido) acetic aciden_US
dc.subjectinhibition zoneen_US
dc.subjectN,N-diethylamideen_US
dc.subjectantibacterial studyen_US
dc.subjectstreptomycinen_US
dc.titleSynthesis and Antibacterial Activity of N,N- Diethylamide Bearing Benzenesulfonamide Derivativesen_US
dc.typeArticleen_US
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