Ancistroguineines A and B as well as ancistrotectorine-naphthylisoquinoline alkaloids from Ancistrocladus guineënsis
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The isolation of three naphthylisoquinoline alkaloids from the leaves of Ancistrocladus guineënsis is described. Their complete structures were established by spectroscopic, chiroptical and degradative methods. Thus, two hitherto unknown 5,8′-coupled naphthylisoquinolines, named ancistroguineines A and B, were isolated, constituting the first example of a pair of 3-epimeric naphthylisoquinoline alkaloids. Moreover, ancistrotectorine, a 7,3′-coupled alkaloid previously known only from the South-East Asian species Ancistrocladus tectorius, was isolated. Its absolute stereostructure was confirmed by oxidative degradation and by comparison of experimental and calculated CD spectra.
Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry , alkaloids , Ancistrocladus guineënsis , chiroptical , isolation
Bringmann, G., Günther, C., Busemann, S., Schäffer, M., Olowokudejo, J. D., & Alo, B. I. (1998). Ancistroguineines A and B as well as ancistrotectorine-naphthylisoquinoline alkaloids from Ancistrocladus guineensis. Phytochemistry, 47(1), 37-43.