Adenosine deaminase activity in subjects with normal pregnancy, pregnancy induced hypertension and pre-eclampsia

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dc.contributor.authorOladipo, O.O.
dc.contributor.authorAfolabi, B.B.
dc.contributor.authorOkorodudu, A.O.
dc.date.accessioned2020-11-09T09:14:31Z
dc.date.available2020-11-09T09:14:31Z
dc.date.issued2009-05
dc.descriptionStaff Publicationsen_US
dc.description.abstractBoth pregnancy and adenosine deaminase (ADA) are associated with depressed cellular mediated immunity. There is little information on ADA activity in pregnant Africans. To determine the serum levels of adenosine deaminase (ADA) in normal pregnancy and pregnancy complicated by hypertension in Nigerian women. One hundred and twenty-five pregnant women comprising 35 normal non-pregnant women, 35 normal pregnant women, 35 pregnant women with pregnancy induced hypertension and 20 patients with pre-eclampsia were recruited for the study. Serum adenosine deaminase enzyme (ADA) activity was measured by the Giusti and Galanti spectrophotometric method in all study subjects. The mean serum ADA level in the non-pregnant women was higher than that in the normal pregnant women (23.21 +/- 6.3 v 14.69 +/- 3.2, p<0.001). Amongst the pregnant women, mean serum ADA in the hypertensive and pre-eclamptic women was significantly higher than that in the normal pregnant group (p<0.001). These findings indicate a probable decrease in cellular immunity in normal pregnancy and an enhanced cell mediated immunity in pre-eclampsia.en_US
dc.identifier.citationOladipo OO, Afolabi BB, Okorodudu AO. Adenosine deaminase activity in subjects with normal pregnancy, pregnancy induced hypertension and pre-eclampsia. West Afr J Med. 2009 May;28(3):161-4. doi: 10.4314/wajm.v28i3.48441. PubMed PMID: 20306731.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/8897
dc.language.isoenen_US
dc.publisherWest Afr J Meden_US
dc.subjectAdenosine deaminaseen_US
dc.subjectPregnancyen_US
dc.subjectPregnancy-induced hypertensionen_US
dc.subjectPre-eclampsiaen_US
dc.subjectResearch Subject Categories::MEDICINE::Surgery::Obstetrics and women's diseasesen_US
dc.titleAdenosine deaminase activity in subjects with normal pregnancy, pregnancy induced hypertension and pre-eclampsiaen_US
dc.typeArticleen_US
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