The role of the percentage free PSA in the diagnosis of prostate cancer in Blacks: Findings in indigenous West African men using TRUS guided biopsy.
| dc.contributor.author | Tijani, K.H. | |
| dc.contributor.author | Anunuobi, C.N. | |
| dc.contributor.author | Adeyomoye, A.O. | |
| dc.contributor.author | Alabi, T.O. | |
| dc.contributor.author | Lawal, A.O. | |
| dc.date.accessioned | 2019-12-05T08:42:04Z | |
| dc.date.available | 2019-12-05T08:42:04Z | |
| dc.date.issued | 2017 | |
| dc.description | Staff publications | en_US |
| dc.description.abstract | Introduction In Western and Asian literature, the measurement of percentage free prostate specific antigen (%fPSA) has been known to enhance the predictive role of total prostate specific antigen (tPSA) in early prostate cancer (Ca-P) detection. Relationship between the tPSA and Ca-P are known to be influenced by race. To the best of our knowledge, the relationship between %fPSA and Ca-P has not been studied in sub-Saharan Africa using current established biopsy protocol. Objective To evaluate the usefulness of %fPSA in indigenous West African men and determine the appropriate cut-off values that may be used as indication for prostate biopsy in men with tPSA of 4–10 ng/ml. Subjects and methods A total 169 consecutive patients with tPSA of 4–10 ng/ml with non-suspicious findings on digital rectal examination (DRE) had a transrectal ultrasound (TRUS) guided 10-core prostate biopsy. The technique of PSA analysis was the Access hybritech assay technique using the Beckman's Access autoimmuno analyser. The rates of prostate cancer in different %fPSA ranges were evaluated. Receiver operating characteristic curve (ROC) was used to evaluate the efficiency of %fPSA in the diagnosis of prostate cancer. Results A reduction %fPSA was associated with a higher detection rate of Ca-P. There was a 62% prevalence of Ca-P with %fPSA ≤ 10% while there was a zero prevalence in patients with fPSA above 20%. At a %fPSA cut off of 20% the sensitivity and specificity were 100% and 45%, respectively. Using the ROC curve, the area under the curve (AUC) was 0.76 while the ROC decision plot showed that a %fPSA cut off 15% was associated with the highest ability to discriminate between benign and malignant diseases. Conclusion The %fPSA is an effective discriminating tool in determining the need for prostate biopsy in indigenous West African men with PSA 4–10 ng/ml. A cut off of 15% was associated with the highest performance | en_US |
| dc.description.sponsorship | UNILAG CRC grant | en_US |
| dc.identifier.citation | Tijani KH, Anunobi CC, Adeyomoye AO, Alabi TO, Lawal AO. The role of the percentage free PSA in the diagnosis of prostate cancer in Blacks: Findings in indigenous West African men using TRUS guided biopsy. African Journal of Urology 2015;23(1):14-19 | en_US |
| dc.identifier.issn | 1110-5704 | |
| dc.identifier.other | https://doi.org/10.1016/j.afju.2016.04.008 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/7036 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.ispartofseries | African Journal of Urology;Vol.23(1) | |
| dc.subject | Free PSA | en_US |
| dc.subject | prostate cancer | en_US |
| dc.subject | west African men | en_US |
| dc.subject | Nigeria | en_US |
| dc.subject | Research Subject Categories::MEDICINE::Surgery | en_US |
| dc.title | The role of the percentage free PSA in the diagnosis of prostate cancer in Blacks: Findings in indigenous West African men using TRUS guided biopsy. | en_US |
| dc.type | Article | en_US |