Substituent effect on spectral and antimicrobial activity of Schiff bases derived from aminobenzoic acids
No Thumbnail Available
Date
2013-10-02
Authors
Ejiah, F.N.
Fasina, T.M.
Familoni, O.B.
Ogunsola, F.T.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The dependence of electronic absorption spectra antimicrobial property on the substituent position was investigated using three Schiff bases derived from salicylaldehyde and isomeric aminobenzoic acids in three solvents of different polarities. The absorption maxima in all three solvents exhibited dependence on the position of substituent with the absorption maxima undergoing a red shift as solvent polarity increased. The in vitro antibacterial activity of the compounds
against some clinically important bacteria namely Escherichia coli (ATCC 25922), Pseudomonas aeruginosa
(ATCC 27853), Staphylococcus aureus (ATCC 25923), Enterococcus feacalis (ATCC 29212) was determined in N,N”-dimethylformamide and 1,4-dioxane using the agar dilution method. The results revealed that the ortho and meta substituted Schiff bases exhibited better antimicrobial activity in the non-polar solvent
Description
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry , Schiff Base , Aminobenzoic Acid , Antibacterial Activity , Salicyaldehyde , Electronic Spectra
Citation
Ejiah, F. N., Fasina, T. M., Familoni, O. B., & Ogunsola, F. T. (2013). Substituent effect on spectral and antimicrobial activity of Schiff bases derived from aminobenzoic acids. Advances in Biological Chemistry, 3(05), 475.