Processing and Evaluation of Locally Sourced Kaolin for Pharmaceutical Production

Simple item page
dc.contributor.authorAdeluola A.O
dc.contributor.authorEzeobiora C.E
dc.contributor.authorMendie U.E
dc.date.accessioned2022-01-16T19:05:29Z
dc.date.available2022-01-16T19:05:29Z
dc.date.issued2018
dc.descriptionFrom the processing, analysis and characterization of kaolin samples from Abia and Ogun States, it can be concluded that these locally sourced clays can be employed in drug production after wet processing technique and leaching with hydrochloric acid. The major microbial contaminants of raw kaolin samples found to be Bacillus subtilis, E. coli, Aspergillus spp. and Histoplasma spp. were absent and the microbial loads of the samples were greatly reduced after hydrochloric acid treatment. Wet processing and leaching of both kaolin samples (AB and OG) with hydrochloric acid at 2 mol/l concentration gave better pharmaceutical-grade kaolin when compared with the standard sample hence could be employed in processing locally sourced kaolin for drug production.en_US
dc.description.abstractCheaper and readily available natural clay deposits in Nigeria, may serve as good sources of pharmaceutical raw material. This work sought to process, characterize and evaluate locally sourced kaolin for drug production. Kaolin samples were locally sourced from Abia state and Ogun state of Nigeria. Purification was done through wet processing and chemical treatment of the samples. Chemical leaching was done using 2mol/l, 4mol/l and 8mol/l concentrations of hydrochloric acid with subsequent boiling for 6 hours. They were subjected to identification test for kaolin, carbonate test and iron limit test. The physicochemical properties were assessed. Samples were characterized using X-Ray Flourescence (XRF), Fourier Transform Infrared (FT-IR), X-Ray Diffraction (XRD) and micrograph. The raw, treated and standard kaolin samples were assessed for microbiological quality. The physicochemical properties and microbial limit tests for their formulated suspensions were also assessed. All the treated powdered samples, complied with pharmacopoeial standards for kaolin. The micrograph showed that the particles are small, clustered and granular. Bacillus subtilis, E. coli, Aspergillus spp. and Histoplasma spp. were identified only in the raw kaolin samples, while the Acid treated samples had acceptable pharmacopoeial standards for microbial limit. XRF, XRD and FT-IR results revealed that 2 mol/l HCl treated samples gave better pharmaceutical-grade kaolin. The suspensions formulated from the treated kaolin samples showed good physicochemical properties and microbial limit. This research reveals that Wet Processing Technique and 2 mol/l HCl leaching is suitable for processing locally sourced kaolin for drug production.en_US
dc.identifier.citationAdeluola A.O, Ezeobiora C.E, Mendie U.E (2018). Processing and Evaluation of Locally Sourced Kaolin for Pharmaceutical Production. Trop J Nat Prod Res. 2(8):388-395.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10431
dc.language.isoen_USen_US
dc.subjectKaolinen_US
dc.subjectwet processingen_US
dc.subjectacid leachingen_US
dc.subjectmicrobial limiten_US
dc.titleProcessing and Evaluation of Locally Sourced Kaolin for Pharmaceutical Productionen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Paper on Kaolin as published_manuscript_302_TJNPR-2018-M92A Proof.pdf
Size:
1.04 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Pharmaceutics and Pharmaceutical Technology- Scholarly Publications