Polymorphism of the endothelial nitric oxide synthase gene is associated with diabetic retinopathy in a cohort of West Africans

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dc.contributor.authorChen, Y
dc.contributor.authorHuang, H
dc.contributor.authorZhou, J
dc.contributor.authorDoumatey, A
dc.contributor.authorLashley, K
dc.contributor.authorChen, G
dc.contributor.authorAgyenim-Boateng, K
dc.contributor.authorEghan, B.A
dc.contributor.authorAcheampong, J
dc.contributor.authorFasanmade, O
dc.contributor.authorJohnson, T
dc.contributor.authorAkinsola, F.B
dc.contributor.authorOkafor, G
dc.contributor.authorOli, J
dc.contributor.authorEzepue, F
dc.contributor.authorAmoah, A
dc.contributor.authorAkafo, S
dc.contributor.authorAdeyemo, A
dc.contributor.authorRotimi, C.N
dc.date.accessioned2019-12-11T11:02:31Z
dc.date.available2019-12-11T11:02:31Z
dc.date.issued2007-04
dc.descriptionStaff publicationsen_US
dc.description.abstractPurpose: In addition to chronic hyperglycemia, there is increasing evidence that genetic factors may be important in the development of diabetes retinopathy (DR). Specifically, polymorphisms of the endothelial nitric oxide synthase gene (eNOS) have been reported to be associated with multiple health conditions including DR, hypertension, nephropathy, and cardiovascular diseases in several ethnic groups. However, there is a paucity of similar data in African Americans and other African populations. To address this issue, we investigated the potential association between polymorphisms of the eNOS gene and diabetes-related phenotypes in 384 persons with type 2 diabetes and 191 controls from two West African countries (Ghana and Nigeria). Methods: We genotyped the deletion/insertion (4a/b) and the G894T polymorphisms of eNOS gene in a total of 575 persons. Results: The b/b genotype of the polymorphism was associated with a 2.4 fold increased risk of DR (95% CI 1.39-4.09). In contrast, we did not observe any association between the genotypes or alleles of G894T polymorphism with DR, hypertension, or nephropathy. Conclusions: We observed a significant association between the 4a/b polymorphism of the eNOS and DR in our West African cohort.en_US
dc.identifier.citationChen Y, Huang H, Zhou J, Doumatey A, Lashley K, Chen G, Agyenim-Boateng K, Eghan BA, Acheampong J, Fasanmade O, Johnson T, Akinsola FB, Okafor G, Oli J, Ezepue F, Amoah A, Akafo S, Adeyemo A, Rotimi CN. Polymorphism of the endothelial nitric oxide synthase gene is associated with diabetic retinopathy in a cohort of West Africans. Molecular Vision 2007; 13:2142-7en_US
dc.identifier.issn1090-0535
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7079
dc.language.isoenen_US
dc.subjectChronic hyperglycemiaen_US
dc.subjectGenetic factorsen_US
dc.subjectEthnic groupsen_US
dc.subjectHealth conditionsen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titlePolymorphism of the endothelial nitric oxide synthase gene is associated with diabetic retinopathy in a cohort of West Africansen_US
dc.typeArticleen_US
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