SYNTHESIS, CHARACTERIZATION AND STRUCTURE ACTIVITY RELATIONSHIP OF SCHIFF BASES DERIVED FROM 2-AMINOPHENOL AND SUBSTITUTED BENZALDEHYDES

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dc.contributor.authorFasina, T.M.
dc.contributor.authorEjiah, F.N.
dc.contributor.authorOloba-Whenu, O.A.
dc.contributor.authorRevaprasadu, N.
dc.contributor.authorFamiloni, O.B.
dc.date.accessioned2019-09-05T09:53:35Z
dc.date.available2019-09-05T09:53:35Z
dc.date.issued2017
dc.description.abstractThe structure-antibacterial activity of six Schiff bases synthesized from 2-aminophenol and substituted benzaldehydes was studied by relating the effect of substituent groups on antibacterial activity. The study showed that compounds with electron donating methoxy substituent exhibited higher inhibitory activity against the tested microorganisms than compounds bearing an electron withdrawing chloroor nitro substituent. Quantum chemical studies carried out on the compounds using density functional theory calculations (DFT) revealed that the activity of the Schiff bases is related to the electrostatic potential, ionization potential and alignment of the dipole moment with respect to the imine bond.en_US
dc.identifier.citationFasina, T. M., Ejiah, F., Oloba-Whenu, O. A., Revaprasadu, N., & Familoni, O. B. SYNTHESIS, CHARACTERIZATION AND STRUCTURE ACTIVITY RELATIONSHIP OF SCHIFF BASES DERIVED FROM 2-AMINOPHENOL AND SUBSTITUTED BENZALDEHYDES.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5161
dc.language.isoenen_US
dc.publisherftstjournal.comen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Physical organic chemistryen_US
dc.subject2-aminophenolen_US
dc.subjectantibacterial activityen_US
dc.subjectSchiff Baseen_US
dc.subjectDFT studyen_US
dc.titleSYNTHESIS, CHARACTERIZATION AND STRUCTURE ACTIVITY RELATIONSHIP OF SCHIFF BASES DERIVED FROM 2-AMINOPHENOL AND SUBSTITUTED BENZALDEHYDESen_US
dc.typeArticleen_US
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