Dysglycaemia in patients with pulmonary tuberculosis in Ilorin.

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Sanni, N
Odeniyi, I.A
Olarinoye, J.K
Fasanmade, O.A
Ohwovoriole, A.E
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Endocrinology and Metabolism Society of Nigeria
BACKGROUND: There is a bidirectional relationship between tuberculosis (TB) and diabetes mellitus (DM). Nigeria is a country with a high burden of DM and TB. How common glucose intolerance is in pulmonary tuberculosis (PTB) among Nigerians has not been well described. OBJECTIVES: The objective of this study was to determine the spectrum of glucose tolerance in adult Nigerian out-patients with PTB. PARTICIPANTS AND METHODS: This study was a cross-sectional observational study involving patients with PTB. Glucose tolerance of patients with PTB was determined by an oral glucose tolerance test. Data was obtained for history, physical examinations and anthropometric measurements. The W.H.O. criteria were used to define categories of dysglycaemia. Data entry and management was done using Excel and the statistical analysis was done using statistic package for social sciences (SPSS) version 20. Results are presented as tables and figures. Descriptive statistics are presented as percentages, median and interquartile ranges. Statistical significance was defined as p-value of < 0.05. RESULTS: One hundred and seventy-seven patients with PTB completed the study, of which 100 (56.5%) participants were male and 77 (43.5%) were female. The median age, weight, body mass index and waist-to-hip ratios of the PTB patients were 32 years, 54kg, 19.1kg/m2 and 0.85 respectively Overall glucose intolerance occurred in 76 (42.9%) of the participants with no significant difference between men and women. The occurrences of normal glucose tolerance, pre-diabetes and DM were 101 (57.1%), 46 (26.0%) and 30 (16.9%) respectively. Of the 30 patients with DM and PTB, 19 (63.3%) were previously undiagnosed while the remaining 11 were already established DM cases. CONCLUSION: Dysglycaemia is more common in PTB patients than in the general Nigerian population. PTB Patients with undiagnosed DM are more than those with known diagnoses.
Diabetes mellitus, dysglycaemia, glucose intolerance, tuberculosis
Sanni N, Odeniyi IA, Olarinoye JK, Fasanmade OA, Ohwovoriole AE. Dysglycaemia in patients with pulmonary tuberculosis in Ilorin. EMSON Book of abstracts