Synthesis of 4H‐3,3a‐dihydrothiazolo[4,3‐b]quinazolines

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dc.contributor.authorAdegoke, E.A.
dc.contributor.authorAlo, B.I.
dc.contributor.authorFamiloni, O.B.
dc.date.accessioned2019-08-30T08:22:20Z
dc.date.available2019-08-30T08:22:20Z
dc.date.issued1987-01
dc.description.abstractRegiospecific synthesis of 4H‐3,3a‐dihydrothiazolo[4,3‐b]quinazolines and 7‐methyl‐4H‐3,3a‐dihydrothiazolo[4,3‐b]quinazolines IVa and IVb is described. The N‐substituted thiazolidinecarboxylic acids Ia and Ib were converted to the corresponding acid chlorides, IIa and IIb but neither reacted with silver trifluoromethanesulphonate. The carboxylic acids Ic and Id were however, decarboxylated to the corresponding iminium ions using phosphorus oxychloride and these afforded the nitroamines IIIa and IIIb. Reductive cyclisation led to the quinazolines IVa and IVb.en_US
dc.identifier.citationAdegoke, E. A., Alo, B. I., & Familoni, O. B. (1987). Synthesis of 4H‐3, 3a‐dihydrothiazolo [4, 3‐b] quinazolines. Journal of heterocyclic chemistry, 24(1), 107-110.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/4891
dc.language.isoenen_US
dc.publisherJournal of Heterocyclic Chemistryen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistryen_US
dc.subjectsynthesisen_US
dc.subjectreductive cyclisationen_US
dc.subject4H‐3,3a‐dihydrothiazolo[4,3‐b]quinazolinesen_US
dc.subjectiminium ionsen_US
dc.titleSynthesis of 4H‐3,3a‐dihydrothiazolo[4,3‐b]quinazolinesen_US
dc.typeArticleen_US
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