Potentials of Ethanol Extracts of Infected Florets of Panicum Maximum Jacq in Evoking Uterine Contraction in Sprague-Dawley Rats
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Asian Research Publishing Network
The contractility effects of aqueous, ethanol and chloroform crude extracts (0.0312-2.0mg/ml final bath concentration (FBC) and purified ethanol fractions (0.001-3.0 mg/ml final bath concentration) of infected Panicum maximum floret were evaluated on primed isolated rat uterus in the presence of ergometrine (10-5-10-2 mol/L). The crude aqueous, ethanol and chloroform extracts produced dose-dependent contraction of the uterus with ethanol extract being more potent than others, with the least dose achieving 77% contraction at FBC of 0.062mg/ml. Through the bioassayguided fractionation, ethanol fraction produced a similar pattern of contraction with standard drug (ergometrine). Out of the three compounds detected in the ethanol fraction on further purification, the compound with Rf value of 0.20 (identified to be alkaloid) was active. These findings suggest the possible use of this compound as a new type of uterotonic agent for uterine contraction.
Contractility , Alkaloid
Kanife, U.C, Adekunle, A.A and Odesanmi, O.S (2012) Potentials of Ethanol Extracts of Infected Florets of Panicum Maximum Jacq in Evoking Uterine Contraction in Sprague-Dawley Rats. ARPN Journal of Agricultural and Biological Science 7(6)