Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria
| dc.contributor.author | Bankole, A. E. | |
| dc.contributor.author | Adekunle, A.A. | |
| dc.contributor.author | Sowemimo, A. A. | |
| dc.contributor.author | Umebese, C. E. | |
| dc.contributor.author | Abiodun, O. | |
| dc.contributor.author | Gbotosho, G. O. | |
| dc.date.accessioned | 2019-08-29T09:27:48Z | |
| dc.date.available | 2019-08-29T09:27:48Z | |
| dc.date.issued | 2016 | |
| dc.description | Scholarly article | en_US |
| dc.description.abstract | The use of plant to meet health-care needs has greatly increased worldwide in the recent times. The search for new plant-derived bioactive agents that can be explored for the treatment of drug-resistant malaria infection is urgently needed. Thus, we evaluated the antimalarial activity of three medicinal plants used in Nigerian folklore for the treatment of malaria infection. A modified Peter’s 4-day suppressive test was used to evaluate the antimalarial activity of the plant extracts in a mouse model of chloroquine-resistant Plasmodium berghei ANKA strain. Animals were treated with 250, 500, or 800 mg/kg of aqueous extract. It was observed that of all the three plants studied, Markhamia tomentosa showed the highest chemosuppression of parasites of 73 % followed by Polyalthia longifolia (53 %) at day 4. All the doses tested were well tolerated. Percentage suppression of parasite growth on day 4 post-infection ranged from 1 to 73 % in mice infected with P. berghei and treated with extracts when compared with chloroquine diphosphate, the standard reference drug which had a chemosuppression of 90 %. The percentage survival of mice that received extract ranged from 0 to 60%(increased as the dose increases to 800 mg/kg). Phytochemical analysis revealed the presence of tannins, saponins, and phenolic compounds in all the three plants tested. | en_US |
| dc.identifier.citation | Bankole, A. E., [Et...al] (2016). Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria. Parasitology Research Vol.115: 299 - 305pp. | en_US |
| dc.identifier.issn | 1432-1955 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/4849 | |
| dc.language.iso | en | en_US |
| dc.publisher | Springer Berlin Heidelberg | en_US |
| dc.relation.ispartofseries | Parasitology Research;Vol.115 | |
| dc.subject | Markhamia tomentosa | en_US |
| dc.subject | Plasmodium berghei | en_US |
| dc.subject | Polyalthia longifolia | en_US |
| dc.subject | Trichilia Heudelotii | en_US |
| dc.subject | Research Subject Categories::NATURAL SCIENCES | en_US |
| dc.title | Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria | en_US |
| dc.type | Article | en_US |