Phytochemical, Chemical and Biomedical Characterization of Crude Extracts of Macrosphyra longistyla (DC.) Hiern

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dc.contributor.authorDurugbo, E. U.
dc.contributor.authorOgah, J. O.
dc.contributor.authorChukwuemeka, N
dc.contributor.authorSename, P. G.
dc.contributor.authorOlukanni, A. T.
dc.contributor.authorYusuf, K. O.
dc.contributor.authorAwuzie, I. C.
dc.contributor.authorOlukanni, A. T.
dc.contributor.authorAboaba, O. O.
dc.date.accessioned2022-09-08T13:37:15Z
dc.date.available2022-09-08T13:37:15Z
dc.date.issued2020-09-15
dc.descriptionScholarly articleen_US
dc.description.abstractPhytochemical analysis of Macrosphyra longistyla leaf, stem bark, and root extracts revealed different constituents. The GCMS analyses of their ethanolic extracts showed the presence of bioactive compounds: the stem bark yielded 9 compounds, such as squalene, vitamin E, and fatty acids; the root extract revealed 10 different compounds, especially morpholine, isophorone and fatty acids. The extracts demonstrated high proteinase inhibition potentials. The aqueous, ethanol and ethyl acetate extracts of the leaf, stem bark, and root were tested against Methicillin-Resistant Staphylococcus aureus (MRSA) 144m, Escherichia coli ATCC11229, Salmonella typhimurium ATCC13311, Enterococcus faeciumATCC700221, Shigella flexneri ATCC12012 and laboratory strain of Streptococcus mutans with the diameter of zone of inhibitions ranging from 10 to 40 mm. The study revealed a marked susceptibility pattern of the test organisms to the ethanol and ethyl-acetate extracts showing varied diameter of zones of inhibitions. The aqueous extract was ineffective against the pathogens. The minimum inhibitory concentrations (MIC) ranged from 25-100mg/ml. All the test organisms except S. mutans were susceptible to control antibiotic (streptomycin 10μg). The presence of arrays of bioactive ingredients implicated in the treatment of specific ailments has provided a scientific justification for Macrophyla longistyla as an alternative remedy for the treatment of bacterial infections.en_US
dc.identifier.citationDurugbo, E.U., Ogah, J.O., Chukwuemeka, N., Sename, P.G., Olukanni, A.T., Yusuf, K.O., Awuzie, I.C., Olukanni, O.D. and Aboaba, S.O., 2021. Phytochemical, Chemical and Biomedical Characterization of Crude Extracts of Macrosphyra longistyla (DC.) Hiern. Jordan Journal of Biological Sciences, 14(3).en_US
dc.identifier.issn1995-6673
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/11369
dc.language.isoenen_US
dc.publisherJordan Journal of Biological Sciencesen_US
dc.subjectMacrosphyra longistylaen_US
dc.subjectDPPH scavengingen_US
dc.subjectisophoroneen_US
dc.subjectplants alkyneen_US
dc.subjectantibacterial agentsen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titlePhytochemical, Chemical and Biomedical Characterization of Crude Extracts of Macrosphyra longistyla (DC.) Hiernen_US
dc.typeArticleen_US
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