Her-2 Over-Expression in Gastric Carcinoma-A 5-Year Retrospective Study in a Lagos Cohort Population
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Date
2015
Authors
Onyekwelu, VI
Badmos, KB
Awolola, NA
Abdulkareem, FB
Journal Title
Journal ISSN
Volume Title
Publisher
West African Journal of Medicine
Abstract
BACKGROUND: Gastric cancer is the fifth most common cancer
and the prognosis has remained poor over the decades due to a
high percentage of advanced stage presentation.
OBJECTIVE: To determine the frequency of HER-2 overexpression
in gastric carcinoma in aLagoscohort population,
comparing it with known clinico-pathologic and prognostic
factors.
MATERIALS AND METHODS: Data on 54 patients with gastric
carcinoma were retrieved from the Histopathology Department
of Lagos University Teaching Hospital. Haematoxylin and Eosin
slides were made from the patients’ paraffin blocks. These were
reviewed for confirmation of diagnosis and determination of
pathological prognostic factors. HER-2 over-expression was
assessed using immunohistochemistry. The data was analyzed
using SPSS 16.
RESULTS: Forty-two gastric biopsies and twelve gastrectomy
specimens were available for study from the 54 patients. The
ages ranged from 30 to 83 years (mean = 55.96 years). The male
to female ratio was 3.2:1. Majority of the carcinomas were
intestinal type (83.3%), with diffuse, mixed and indeterminate
types accounting for 13%, 1.9% and 1.9% respectively. About
44% of the cases were moderately-differentiated grade and
patients who had gastrectomies presented mostly with stage T3
disease (75%). HER-2 was over-expressed in 13% of cases, with
one equivocal case. There were no statistically significant
associations between HER-2 over-expression and the prognostic
factors.
CONCLUSION: HER-2 over-expression occurs in a small
percentage of gastric carcinoma in Lagos and is independent of
most of the pathological parameters. Further work, with larger
cohort, is needed to better characterize the possible prognostic
benefits of targeted anti-HER-2 therapy in gastric carcinomas
Description
Keywords
Gastric carcinoma; Prognostic Factors; HER-2 Over- Expression; Immunohistochemistry; Intestinal Type
Citation
WAJM 2015; 34(3): 150–156