Impact of Yoyo bitters® on the Pharmacokinetic Profile of Ciprofloxacin in Healthy Nigerian Volunteers

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dc.contributor.authorMartins O.C.
dc.contributor.authorAkinleye M.O.
dc.contributor.authorUkpo G.E.
dc.contributor.authorAdepoju-Bello A.A.
dc.contributor.authorOdediran b.b.
dc.contributor.authorOnun O.O.
dc.contributor.authorMakinde P.A.
dc.date.accessioned2022-01-01T17:12:15Z
dc.date.available2022-01-01T17:12:15Z
dc.date.issued2018
dc.descriptionScholarly articlesen_US
dc.description.abstractCiprofloxacin and Yoyo bitters® (a liquid herbal oral preparation) are readily and widely available as prescription drug and herbal medicine, respectively in Nigeria. They are taken separately or concomitantly. The high metal content of Yoyo bitters poses to be a potential problem for the bioavailability of fluoroquinolones. Thus, this study was carried out to investigate the possible drug-herb interaction between Ciprofloxacin tablet and Yoyo bitters when co-administered. Pharmacokinetics of oral single dose ciprofloxacin (500 mg) tablet was evaluated in 30 healthy volunteers. The study design was an open, single dose randomized two-way comparative crossover treatment groups. Each group either took ciprofloxacin (500 mg) tablet with 200 mL of water or ciprofloxacin with 30 mL of yoyo bitters. A wash out period of two weeks was observed, and the treatment groups were interchanged. Blood samples were collected and analyzed for ciprofloxacin in plasma using a modified High-Performance Liquid Chromatographic (HPLC) method with UV detector at 278nm. Non-compartmental analysis was employed for pharmacokinetic parameters estimation. Results indicated that Yoyo bitters altered the Pharmacokinetics of ciprofloxacin (Cmax, AUC, Vd, Tmax, t1/2, Kel and Kab) when administered concomitantly, although not statistically significant (p>0.05). Therefore, for the desired therapeutic effect of ciprofloxacin to be optimally achieved, concomitant administration with Yoyo bitters or any herbal preparation should be staggered. Keywords: Ciprofloxacin, Drug-Herb interaction, Pharmacokinetics, Yoyo bitters®en_US
dc.description.sponsorshipSelfen_US
dc.identifier.citationOlubukola C. Martins, Moshood O. Akinleye, Grace E. Ukpo, Aderonke A. Adepoju-Bello, Bukola B. Odediran, Esther O. Onun, Paul A. Makinde (2018). Impact of Yoyo bitters® on the Pharmacokinetic Profile of Ciprofloxacin in Healthy Nigerian Volunteers. Trop J Nat Prod Res, October 2018; 2(10):456-459en_US
dc.identifier.issn2616-0692
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9873
dc.language.isoenen_US
dc.publisherTrop J Nat Prod Res.en_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.subjectDrug herb interactionen_US
dc.subjectPharmacokineticsen_US
dc.subjectCiprofloxacinen_US
dc.subjectYoyo bittersen_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmaceutical pharmacologyen_US
dc.titleImpact of Yoyo bitters® on the Pharmacokinetic Profile of Ciprofloxacin in Healthy Nigerian Volunteersen_US
dc.typeArticleen_US
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