Metallo-Β Lactamase Production by Escherichia Coli and Klebsiella Species Isolated from Hospital and Community Subjects in Lagos, Nigeria.
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Metallo β-lactamases (MBL) producing Enterobacteriaceae are of clinical concern globally. β-Lactam antibiotic is the treatment option for serious bacterial infections. Carbapenems is active against Extended-Spectrum β-lactamase (ESBL) producing Enterobacteriaceae, particularly, Escherichia coli and Klebsiella pneumonia; Cephalosporinases and carbapenemases producers as well. This study was designed to evaluate Metallo β-Lactamase producing E. coli and Klebsiella spp amongst hospitalized and community subjects in Lagos Nigeria, between March and July 2008. Sixty bacteria from hospital and community were analyzed. Antimicrobial susceptibility and Metallo- β-Lactamase-Production were determined using Disk Diffusion method, Double Disk Synergy Test and Combined Disk Test respectively. Carbapenems had the highest (100%) activity against the bacteria tested. Two strains of Kleb. spp susceptible to imipenem were found to be MBL producers. Ceftazidime had 52% resistance in both organisms. Among the 17 strains of E. coli from hospital patients, 7 were resistant to ceftazidime and were found to be MBL producers. Out of the 24 Kleb. spp (hospital) tested, 8 were resistant to ceftazidime, and 4/8 were subsequently found to be MBL producers. One E. coli and two Kleb. spp were resistant to ceftazidime; and only one strain of Kleb. spp was found to be MBL producer from the community. Metallo-β-Lactamase in E. coli and Kleb Spp. is a threat within the hospital and community studied from the public health view point. Early detection of MBL-producers routinely in clinical laboratories is a tool for its containment and is hereby advocated.
Bacteria , Metallo -β-Lactamase , Hospital , Community , Research Subject Categories::PHARMACY
Enwuru NV, Enwuru CA, Ogbonnia SO, Adepoju-Bello AA (2011). Metallo-Β Lactamase Production by Escherichia Coli and Klebsiella Species Isolated from Hospital and Community Subjects in Lagos, Nigeria. Nature and Science; 9 (11):1-5.