Association of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adults
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Date
2018
Authors
Ogundele, O.E
Adekoya, K.O
Osinubi, A.A
Awofala, A.A
Journal Title
Journal ISSN
Volume Title
Publisher
Egyptian Journal of Medical Human Genetics
Abstract
Background: The association of obesity with adiponectin gene has been reported in different populations with various inconsistencies. Data from Nigeria is very scanty on the association.
Aim: We investigated possible associations of adiponectin gene (ADIPOQ) single nucleotide polymor- phisms (SNPs) rs2241766 (+45T>G in exon 2), rs266729 (!11377C>G in promoter) and rs1501299 (+276G>T in intron 2) with body mass index (BMI), waist circumference (WC) and hip circumference (HC), in our cross-sectional study.
Subjects and methods: SNPs in ADIPOQ were genotyped in 107 subjects (81 females, 26 males; mean age 22.2years) by Sequenom MassARRAY. Notably, rs2241766 was removed for not reaching Hardy-Weinberg equilibrium. BMI was calculated (kg/m2) while WC and HC were measured using stan- dard procedures
Results: Linear regression showed that variant rs1501299 was not associated with BMI, WC or HC but rs266729 was associated with increased measures of obesity involving BMI (recessive model; beta coefficient [b], 12.85; 95% confidence interval [CI], 6.47, 19.24, codominant model; GG, b, 13.08; 95% CI, 6.71, 19.46, GC, b, 1.04; 95% CI, !0.60, 2.68 and log-additive model; b, 2.117; 95% CI, 0.55, 3.68), WC (recessive model; b, 22.17; 95% CI, 7.11, 37.23 and codominant model; GG, b, 21.857; 95% CI, 6.74, 36.98, GC, b, !1.459; 95% CI, !5.34, 2.43) and HC (recessive model; b, 33.56; 95% CI, 15.41, 51.70, codom- inant model; GG, b, 34.171; 95% CI, 16.04, 52.30, GC, b, 2.771; 95% CI, !1.79, 7.34 and log-additive model; b, 5.466; 95% CI, 1.14, 9.80).
Conclusion: This study in young Nigerian adults confirmed previously reported association of SNP !11377C>G with obesity measures in other populations.
Description
Scholarly articles
Keywords
Obesity , Nigeria , Adiponectin gene , Genes , Research Subject Categories::MEDICINE
Citation
Ogundele O.E., Adekoya, K.O., Osinubi, A.A.A., Awofala, A.A., & Oboh B.O. (2017). Association of adiponectin gene (ADIPOQ) polymorphisms with measures of obesity in Nigerian young adults. Egyptian Journal of Medical Human Genetics, 19:123-127. http://dx.doi.org/10.1016/j.ejmhg.2017.08.005.