Evaluation of Antioxidant Activity of Tetracarpidium conophorum (M¨ull. Arg) Hutch & Dalziel Leaves

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Amaeze O.U.
Ayoola G.A.
Sofidiya M.O.
Adepoju-Bello A.A.
Adegoke A.O.
Coker H.A.B.
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Oxidative Medicine and Cellular Longevity
This study evaluated the antioxidant activity as well as bioflavonoid content of the methanol and ethanol-water extracts of the freshand dried leaves of Tetracarpidium conophorum. Antioxidant activity was determined by spectrophotometricmethods using DPPH.free radical, nitric oxide radical inhibition and ferric reducing antioxidant power assays. In addition, total phenolics, flavonoids.and proanthocyanidin content were also determined. The ethanol: water extract of the dried leaves had the highest antioxidant activity with a 50% inhibition of DPPH at a concentration of 0.017 mg/mL compared to the standards, Vitamin C and Vitamin E with inhibition of 0.019 and 0.011 mg/mL, respectively. This extract also showed nitric oxide radical inhibition activity comparable .to that of rutin, 54.45% and 55.03% for extract and rutin, respectively, at 0.1 mg/mL. Ferric reducing power was also comparable tothat of ascorbic acid (281 and 287 μMFe (11)/g, resp.) at a concentration of 1 mg/mL. The methanol extract of both the dried andthe fresh leaves had higher phenolic, flavonoids and proanthocyanidin content than the ethanol : water extract. The study reveals that T. conophorum can be an interesting source of antioxidants with their potential use in different fields namely food, cosmetics.and pharmaceuticals.
Scholarly articles
Research Subject Categories::PHARMACY , Tetracarpidium conophorum, Antioxidant activity, DPPH, bioflavonoid content , Antioxidant activity , Bioflavonoid content
Amaeze OU, Ayoola GA, Sofidiya MO, Adepoju-Bello AA, Adegoke AO, Coker HAB (2011). Evaluation of Antioxidant Activity of Tetracarpidium conophorum (Müll. Arg) Hutch & Dalziel Leaves. J. Oxidative Medicine and Cellular Longevity. Article ID 976701, 7 pages doi:10.1155/2011/976701.