Spontaneous regeneration of whole mandible after total mandibulectomy in a sickle cell patient.
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Resection of the mandible and immediate reconstruction with autogenous bone graft are widely used in the treatment of ameloblastoma involving a large section of the mandible. The purpose of reconstruction is mainly to rehabilitate the patient esthetically by improving the contour of the mandible, thereby minimizing facial deformity from the defect. The patient is rehabilitated functionally and the occlusal disturbance is minimized. Primary reconstruction by bone grafting is usually advocated at the time of surgery for various reasons. The access to the surgical site is optimal because there is no fibrosis of the graft bed. However, local facilities for surgery, infection, and patients’ general condition may not often permit this. Extensive bone regeneration that reconstitutes 50%1,2 or greater than 50% of the mandible after injury involving a segment of mandible have been reported previously. There is, however, no reported case in which a whole mandible regenerates with condyles. This study presents a rare case of spontaneous regeneration of a whole mandible with the condyles in a 13-year-old Nigerian patient with sickle cell disease who had total mandibulectomy for an extensive case of ameloblastoma.
Spontaneous generation , Mandible , Sickle cell , Total mandibulectomy , Research Subject Categories::ODONTOLOGY
Ogunlewe MO, Akinwande JA, Ladeinde AL, Adeyemo WL. Spontaneous regeneration of whole mandible after total mandibulectomy in a sickle cell patient. J Oral Maxillofac Surg. 2006 Jun;64(6):981-4.