A comparison of the anti-diabetic potential of d-ribose-l-cysteine with insulin, and oral hypoglycaemic agents on pregnant rats.

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dc.contributor.authorOsinubi, A
dc.contributor.authorFasanmade, O.A
dc.contributor.authorSamuel, T.A
dc.contributor.authorMedubi, L.J
dc.contributor.authorKusemiju, T
dc.contributor.authorAkang, E.N
dc.contributor.authorMadu, D
dc.contributor.authorOsolu, J
dc.contributor.authorSodiq, L.K
dc.date.accessioned2019-11-27T14:18:53Z
dc.date.available2019-11-27T14:18:53Z
dc.date.issued2018-08
dc.descriptionStaff publicationsen_US
dc.description.abstractOver 18% of pregnant women are affected by diabetes mellitus (DM) and Insulin has been the commonest drug used in its treatment. There are reports of noncompliance to insulin due to trypanophobia, with suggestions for the use of oral hypoglycaemic agents (OHAs). However, the opposing views about the benefits and risk of oral hypoglycaemic agents (OHAs) warrant a continuous search for an alternative regimen. Therefore, this study is aimed at comparing the antidiabetic effects of d-ribose-l-cysteine (riboceine) with vildagliptin, glibenclamide, metformin, glipizide and insulin in diabetes in pregnancy. Forty (40) female Sprague-Dawley (SD) rats were mated with twenty (20) male SD rats. Diabetes was induced by streptozotocin and the female SD rats were divided into 8 groups of five (5) rats each. The animals were administered either of the OHAs vildagliptin, glibenclamide, metformin, glipizide and riboceine for a period of 19 gestational days. The results showed that streptozotocin (STZ) significantly (p < 0.05) decreased the weights of the animals, increased malondialdehyde, blood glucose levels and altered reproductive hormones. These effects of STZ were better ameliorated in animals that received insulin and riboceine compared to the other OHAs. While progesterone levels were significantly (p < 0.05) higher in animals that received riboceine compared to insulin. Glibenclamide increased (p < 0.05) foetal weights compared to non-diabetic animals. In conclusion, glibenclamide may be a threat to mother`s life in the management of diabetes in pregnancy however, riboceine as well as vildagliptin, metformin and glipizide are effective oral hypoglycaemic agents which could serve as a potent adjuvant comparable to insulin in the management of diabetes during gestation.en_US
dc.identifier.citationOsinubi AAA, Medubi LJ, Akang EN, Sodiq LK, Samuel TA, Kusemiju T, Osolu J, Madu D, Fasanmade O. A comparison of the anti-diabetic potential of d-ribose-l-cysteine with insulin, and oral hypoglycaemic agents on pregnant rats. Toxicol Rep. 2018 Aug 9;5:832-838. doi: 10.1016/j.toxrep.2018.08.003.en_US
dc.identifier.issn2214-7500
dc.identifier.otherdoi: 10.1016/j.toxrep.2018.08.003
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7006
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesToxicol Rep.;Vol.9(5)
dc.subjectDiabetesen_US
dc.subjectGilbenclamideen_US
dc.subjectGlipizideen_US
dc.subjectMetforminen_US
dc.subjectOxidative stressen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleA comparison of the anti-diabetic potential of d-ribose-l-cysteine with insulin, and oral hypoglycaemic agents on pregnant rats.en_US
dc.typeArticleen_US
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