Quality Control Assessment of Twelve Brands ofLevofloxacin Tablets cs, obtained from a Cosmopolitan City
| dc.contributor.author | Adepoju-Bello A.A. | |
| dc.contributor.author | Oguntibeju O.O. | |
| dc.contributor.author | Okekeozo H.U. | |
| dc.contributor.author | Abimbola O.M. | |
| dc.contributor.author | Iloo G.N. | |
| dc.date.accessioned | 2021-12-30T21:34:09Z | |
| dc.date.available | 2021-12-30T21:34:09Z | |
| dc.date.issued | 2014 | |
| dc.description | Scholarly articles | en_US |
| dc.description.abstract | Background: The spread of fake and substandard drugs is a major health problem in both the developed and the developing countries, and the existence of counterfeit and substandard drugs have been increasingly reported in developing countries. Objectives: To assess the physical and quantitative quality of randomly selected brands of levofloxacin tablets marketed in Lagos, Nigeria. Methods: The methods used for the uniformity of weight, friability and disintegration test were obtained from the British Pharmacopoeia (BP). The ultraviolet/visible spectroscopic method was used for the quantitative assay. Results: The results showed that all the samples, L1-L12 passed the uniformity of weight test. All the brands (100 %) passed the hardness/crushing strength test, friability test and disintegration time test. Using the BP specification (95-105 %), all the samples passed the UV visible spectrophotometric analysis. Conclusion: In order to elicit maximum and desired therapeutic effect, drugs are required to fall within specified limits as stared in the pharmacopoeia. Any brand outside this range is termed sub-standard and this may result in therapeutic failure if the quantity is below that specified in the pharmacopoeia or toxicity if above the range. Interestingly in this study, all the twelve brandsanalysed passed the tests. | en_US |
| dc.identifier.citation | Adepoju-Bello A.A. Oguntibeju O.O. Okekeozo H.U. Abimbola O.M. Iloo G.N. (2014).Quality Control Assessment of Twelve Brands ofLevofloxacin Tablets. University of Lagos Journal of Basic Medical Sciences | en_US |
| dc.identifier.issn | 2354-4368 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/9811 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of Lagos Journal of Basic Medical Sciences | en_US |
| dc.subject | Levofloxacin tablets | en_US |
| dc.subject | Physicochemical tests | en_US |
| dc.subject | Quantitative analysis | en_US |
| dc.subject | UV/visible spectrophotometry | en_US |
| dc.subject | Research Subject Categories::PHARMACY::Pharmaceutical chemistry | en_US |
| dc.title | Quality Control Assessment of Twelve Brands ofLevofloxacin Tablets cs, obtained from a Cosmopolitan City | en_US |
| dc.type | Article | en_US |