Anticancer activity of Enterolobium cyclocarpum on cervical and breast cancer cells in vitro

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dc.contributor.authorSowemimo, A.
dc.contributor.authorSpies, L.
dc.contributor.authorHongbin, L.
dc.contributor.authorVan de Venter, M.
dc.date.accessioned2017-10-11T08:08:34Z
dc.date.available2017-10-11T08:08:34Z
dc.date.issued2012-08-01
dc.descriptionConference Paperen_US
dc.description.abstractEthnopharmacological relevance: Enterolobium cyclocarpum (Jacq.) Griseb. is a tropical tree that has folkloric implications against many ailments and diseases including cancer. Materials and methods: To explore the ethnopharmacological claims against cancer, the cytotoxicity of the methanolic extract of the leaves, was investigated using the brine shrimp lethality assay, MTT assay using cervical (HeLa) and breast (MCF7) cancer cell lines, cell cycle analysis and Annexin V-FITC/PI assay. Results: In the brine shrimp lethality assay, the extract showed cytotoxic activity with LC 50 value of 31.63 mg/ mL. Significant growth inhibition was observed in both cell lines with IC 50 values of 2.0771.30 mg/mL and 11.8471.18 mg/mL for HeLa and MCF7, respectively. Cell cycle analysis indicated that HeLa cells were arrested in the G 2 /M phase while MCF7 cells arrested in the G 1 /G 0 phase. The Annexin V-FITC/PI assay revealed phosphatidylserine translocation in both cell lines and thus apoptosis induction upon treatment with the extract. Conclusion: The study demonstrated the potential antiproliferative activity of Enterolobium cyclocarpum thereby supporting the traditional claim and provides basis for further mechanistic studies and isolation of active constituents.en_US
dc.identifier.citationSowemimo,A.,Spies,L.,Hongbin,L.and Van de Venter,M (2012) Anticancer activity of Enterolobium cyclocarpum on cervical and breast cancer cells in vitro. Being a Paper Presented At The 8th Joint Meeting AFERP,,ASP,GA,PSE & SIF, New-York City,U.S.A.en_US
dc.identifier.urihttps://www.researchgate.net/.../275146907_Anticancer_activity_of_Enterolobium_cycl.
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1320809
dc.identifier.urihttp://ir.unilag.edu.ng:8080/xmlui/handle/123456789/2064
dc.language.isoenen_US
dc.subjectBreast Canceren_US
dc.subjectCervicalen_US
dc.titleAnticancer activity of Enterolobium cyclocarpum on cervical and breast cancer cells in vitroen_US
dc.typePresentationen_US
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