Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery.

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dc.contributor.authorBamgbose, B.O.
dc.contributor.authorAkinwande, J.A.
dc.contributor.authorAdeyemo, W.L.
dc.contributor.authorLadeinde, A.L.
dc.contributor.authorArotiba, G.T.
dc.contributor.authorOgunlewe, M.O.
dc.date.accessioned2019-10-25T13:49:59Z
dc.date.available2019-10-25T13:49:59Z
dc.date.issued2005-11-04
dc.descriptionStaff publicationsen_US
dc.description.abstractBACKGROUND: The apparent interactions between the mechanisms of action of non-steroidal anti-inflammatory drugs (NSAIDS) and steroids suggest that co-therapy may provide beneficial inflammatory and pain relief in the absence of side effects. The aim of the study was to compare the effect of co-administered dexamethasone and diclofenac potassium (diclofenac K) with diclofenac K alone on the postoperative pain, swelling and trismus after surgical removal of third molars. PATIENTS AND METHODS: A prospective randomized double-blind study was conducted at the Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, Nigeria. A total of 100 patients were randomly allocated to two treatment groups of dexamethasone (prophylactic 8 mg and postoperative 4 mg IV) and diclofenac K (50 mg Oral before and after surgery), and diclofenac K alone (as with first group). The overall analgesic efficacy of the drug combinations was assessed postoperatively by determination of pain intensity using a category rating scale. Facial swelling was measured using a tape measure placed from tragus to gonion to tragus, while interincisal mouth-opening of patients was measured using a vernier calibrated caliper pre-operatively and post-operatively. RESULTS: Co-administration of dexamethasone and diclofenac K was significantly superior to diclofenac alone for the relief of pain (P < 0.05), and facial swelling up to post-operative 48 hour (P < 0.05). However, there was no significant difference for trismus relief between the two medication protocols (P > 0.05). CONCLUSION: This study illustrates enhanced effects of co-administered dexamethasone and diclofenac K on short-term post-operative pain and swelling, compared to diclofenac potassium alone in third molar surgery.en_US
dc.identifier.citationBamgbose BO, Akinwande JA, Adeyemo WL, Ladeinde AL, Arotiba GT, Ogunlewe MO. Effects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery. Head Face Med. 2005 Nov 7;1:11.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6533
dc.language.isoenen_US
dc.publisherBMCen_US
dc.relation.ispartofseriesHead Face Med.;Vol.7
dc.subjectDexamethasoneen_US
dc.subjectDiclofenac potassiumen_US
dc.subjectThird molar surgeryen_US
dc.subjectPainen_US
dc.subjectSwellingen_US
dc.subjectTrismusen_US
dc.subjectResearch Subject Categories::ODONTOLOGYen_US
dc.titleEffects of co-administered dexamethasone and diclofenac potassium on pain, swelling and trismus following third molar surgery.en_US
dc.typeArticleen_US
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