Effect of nevirapine, efavirenz and lopinavir/ritonavir on the therapeutic concentration and toxicity of lumefantrine in people living with HIV at Lagos University Teaching Hospital, Nigeria

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dc.contributor.authorUsman, S.O.
dc.contributor.authorOreagba, I.A
dc.contributor.authorAkinyede, A.A.
dc.contributor.authorAgbaje, E.O.
dc.contributor.authorAkinleye, M.O.
dc.contributor.authorOnwujuobi, A.G.
dc.contributor.authorKen-Owotor, C.
dc.contributor.authorAdeuja, O.
dc.contributor.authorOgunfowokan, T.
dc.contributor.authorKogbe, S.
dc.contributor.authorOwolabi, E.T.
dc.contributor.authorAdeniji, H.
dc.contributor.authorBusari, A.
dc.contributor.authorHassan, O.O.
dc.contributor.authorAbideen, G.
dc.contributor.authorAkanmu, A.S.
dc.date.accessioned2022-01-16T19:17:40Z
dc.date.available2022-01-16T19:17:40Z
dc.date.issued2020-08-05
dc.description.abstractPatients living with HIV in malarial endemic regions may experience clinically significant drug interaction between antiretroviral and antimalarial drugs. Effects of nevirapine (NVP), efavirenz (EFV) and lopinavir/ritonavir (LPVr) on lumefantrine (LM) therapeutic concentrations and toxicity were evaluated. In a four-arm parallel study design, the blood samples of 40 participants, treated with artemether/ lumefantrine (AL), were analysed. Lumefantrine Cmax was increased by 32% (p ¼ 0.012) and 325% (p < 0.0001) in the NVP and LPVr arms respectively but decreased by 62% (p < 0.0001) in the EFV-arm. AUC of LM was, respectively, increased by 50% (p ¼ 0.27) and 328% (p < 0.0001) in the NVP and LPVr arms but decreased in the EFV-arm by 30% (p ¼ 0.019). Median day 7 LM concentration was less than 280 ng/ mL in EFV-arm (239 ng/mL) but higher in control (290 ng/mL), NVP (369 ng/mL, p ¼ 0.004) and LPVr (1331 ng/mL, p < 0.0001) arms. There were no clinically relevant toxicities nor adverse events in both control and test arms. Artemether/lumefantrine is safe and effective for treatment of malaria in PLWHA taking NVP and LPVr based ART regimen but not EFV-based regimen.en_US
dc.identifier.citationUsman, S. O., Oreagba, I. A., Akinyede, A. A., Agbaje, E. O., Akinleye, M. O., Onwujuobi, A. G., ... & Akanmu, A. S. (2020). Effect of nevirapine, efavirenz and lopinavir/ritonavir on the therapeutic concentration and toxicity of lumefantrine in people living with HIV at Lagos University Teaching Hospital, Nigeria. Journal of Pharmacological Sciences, 144(3), 95-101.en_US
dc.identifier.issn1347-8613
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10441
dc.language.isoenen_US
dc.publisherScience Directen_US
dc.subjectLumefantrineen_US
dc.subjectAntiretroviral drugsen_US
dc.subjectTherapeutic concentrationsen_US
dc.subjectMalariaen_US
dc.subjectHIVen_US
dc.titleEffect of nevirapine, efavirenz and lopinavir/ritonavir on the therapeutic concentration and toxicity of lumefantrine in people living with HIV at Lagos University Teaching Hospital, Nigeriaen_US
dc.typeArticleen_US
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