Maximizing height using growth hormone in a person with short stature due to chromosomal disorder
| dc.contributor.author | Ede, O.J | |
| dc.contributor.author | Olopade, O.B | |
| dc.contributor.author | Odeniyi, I.A | |
| dc.contributor.author | Fasanmade, O.A | |
| dc.date.accessioned | 2021-09-23T09:53:48Z | |
| dc.date.available | 2021-09-23T09:53:48Z | |
| dc.date.issued | 2021-09-23 | |
| dc.description | Scholarly articles | en_US |
| dc.description.abstract | INTRODUCTION. Chromosomal abnormality is an established cause of short stature (SS). Low self-esteem has been found in individuals with SS impacting negatively on the quality of life. Early diagnosis and administration of human growth hormone (GH) allow attainment of adult height. The objective of this presentation is to discuss the use of recombinant GH therapy in maximizing the height of a Turner syndrome patient. CASE PRESENTATION An 18-year-old schoolgirl presented to the endocrine clinic on account of SS and primary amenorrhoea. Childhood developmental milestones were normal with good academic performance. Her mother and elder sister attained menarche at 16 years, while her younger sister at 13 years. Past medical and surgical history was unremarkable. General examination revealed scanty axillary and pubic hairs. Her height was 1.37m, Weight: 33kg, BMI: 17.6kg/m2, arm span: 1.35m, carrying angle: 15 degrees (10-15 degrees) and Nipple distance: 15cm (0.32-1.07cm). Her breast development was Tanner stage 1. Systemic examinations were normal. Serum GH-0.45ng/ml (0.26-11.7), Oestradiol- 9.47pg/ml(12.5-166), Progesterone-0.42ng/ml (0.2-1.5), FSH-99.200Miu/ml (3.5-12.5), LH- 51.20Miu/ml(2.4-12.6), Prolactin: 244.27uIU/ml (102-496). KARYOTYPE- 45XO. Radiograph of the left wrist - bone age of 11years. Abdominopelvic ultrasound showed a Hypoplastic uterus. A diagnosis of SS secondary to Turner syndrome with hypergonadotropic hypogonadism was made. She was commenced on SC GH 24 notches per day. Treatment was however hampered by financial constraints. Her current height after 2 years of follow-up was 1.48m as at the last review. CONCLUSION: Early initiation of HGH in patients with short stature improves growth and adult height with the better psychosocial outcome | en_US |
| dc.identifier.citation | Ede OJ, Olopade OB, Odeniyi IA, Fasanmade OA. Maximizing height using growth hormone in a person with short stature due to chromosomal disorder. EMSON Book of Abstracts 2021 | en_US |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/9579 | |
| dc.language.iso | en | en_US |
| dc.publisher | Endocrinology and metabolism society of Nigeria | en_US |
| dc.subject | Short Stature | en_US |
| dc.subject | Turner syndrome | en_US |
| dc.subject | Growth Hormone | en_US |
| dc.subject | Hypogonadism | en_US |
| dc.subject | Research Subject Categories::MEDICINE | en_US |
| dc.title | Maximizing height using growth hormone in a person with short stature due to chromosomal disorder | en_US |
| dc.type | Presentation | en_US |