Quality of brands of atorvastatin calcium tablets marketed in Lagos, Nigeria

Simple item page
dc.contributor.authorAkinleye, M.O.
dc.contributor.authorIdris, O.
dc.contributor.authorNwachukwu, P.N.
dc.contributor.authorOyetunde, O.O.
dc.date.accessioned2019-09-17T08:10:51Z
dc.date.available2019-09-17T08:10:51Z
dc.date.issued2012-10-03
dc.descriptionStaff publicationsen_US
dc.description.abstractThis study investigated the quality of atorvastatin calcium tablets marketed in Lagos, Nigeria, by evaluating and comparing their physico-chemical profiles. Evaluation of physico-chemical parameters viz: uniformity of weight, hardness, friability and disintegration test was carried out according to British Pharmacopoeia. Assay of active ingredient and in-vitro dissolution evaluation were conducted using USP Apparatus 2 satisfying the general conditions for film tablets as stipulated in official books. Tablets and dissolution samples were analyzed using a modification of the validated High performance liquid chromatographic method developed by Stanisz and Lukas. All the three brands met the standards for the physical qualities of a satisfactory tablet, and all had percentage purities within the 90 to 110% range. Only brands AT and CT had released ≥75% of label claim of atorvastatin calcium within 45 min, as specified in the B.P for conventional tablets. Thus, brand BT which had barely released 70% of its label claim at 60 min failed dissolution test. We concluded that out of the 3 brands of immediate release atorvastatin calcium tablets available in the market at the time of the study, only 2 passed all the pharmacopoeia tests for satisfactory quality. Thus, only these can be interchanged in clinical practice.en_US
dc.identifier.citationAkinleye, M.O, Idris, O., Nwachukwu, P.N. and Oyetunde, O.O. (2012). Quality of brands of atorvastatin calcium tablets marketed in Lagos, Nigeria.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5647
dc.language.isoenen_US
dc.publisherInternational Scholars journalsen_US
dc.subjectAtorvastatinen_US
dc.subjectin vitro bioequivalenceen_US
dc.subjectswitchabilityen_US
dc.subjectQualityen_US
dc.subjectsafetyen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistryen_US
dc.titleQuality of brands of atorvastatin calcium tablets marketed in Lagos, Nigeriaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Quality.pdf
Size:
411.89 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Pharmaceutical Chemistry- Scholarly Publications